Anti-inflammatory and hemostatic effects of Linaria reflexa Desf

Citation:

Cheriet T, HANFER M, Mancini I, Benelhadj S, Laouas NE, Ameddah S, Menad A, Seghiri R. Anti-inflammatory and hemostatic effects of Linaria reflexa Desf. Natural Product Research [Internet]. 2021;35 (16) :2778-2783.

Date Published:

2021

Abstract:

The work presented here was aimed to investigate the in vivo anti-inflammatory and in vitro hemostatic activities of Linaria reflexa extract and to establish the relationship between its bioactivity and chemical composition. Twenty-three secondary metabolites were identified, most of them are good anti-inflammatory agents, in line with data by carrageenin-induced rat paw edema assays of the n-butanol extract showing high anti-inflammatory inhibition (63.90%) of edema swelling in the rat paw at the dose 200 mg/kg after 4 h. Furthermore, both extent of inflammatory response and tissue injury were prevented keeping the levels of rate myeloperoxidase (60.16%) and of malondialdehyde, which is the final product of lipid peroxidation generated by free radicals (58.58%). The same extract showed also a remarkable hemostatic effect established by measuring the coagulation time of decalcified plasma (45 s), related to its flavonoid glycosides content.

Publisher's Version

Last updated on 09/24/2023