Chemical constituents, in vitro anti-inflammatory, antioxidant and hemostatic activities of then-butanol extract ofHyacinthoides lingulata (Poir.) Rothm

Citation:

HANFER M, Benramdane Z, Cheriet T, Sarri D, Menad A, Mancini I, Seghiri R, Ameddah S. Chemical constituents, in vitro anti-inflammatory, antioxidant and hemostatic activities of then-butanol extract ofHyacinthoides lingulata (Poir.) Rothm. Natural Product Research [Internet]. 2022.

Date Published:

2022

Abstract:

The phytochemical profile obtained from LC-ESI-MS/MS analysis of then-butanol extract (BEHL) from the North African endemic plantHyacinthoides lingulata (Poir.) Rothm. brought about the identification of ten glycosylated derivatives of apigenin and luteolin flavones. For the same plant extract,in vitro anti-inflammatory (hypotonic induced hemolysis and heat induced haemolysis assay) and antioxidant (DPPH andβ-Carotene) activities were evaluated observing high inflammatory inhibition by protecting membrane stability of erythrocyte in both heat (84.70 ± 0.24%) and hypotonic induced hemolysis (79.45 ± 0.12%). A remarkable hemostatic effect was also established by measuring the coagulation time (15.95 ± 1.05 s at a dose of 1 mg/mL) of decalcified plasma related to its phytochemical content. It is the first report on combined chemical components and biological evaluation of this specific plant.

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Last updated on 04/20/2022