Background

Diabetes mellitus is a serious complex multifactorial disorder that imposes huge health and economic burden on societies. Because the currently available medications have many drawbacks, it's important to look for alternative therapies. Medicinal plants utilized in folk medicine are ideal candidates. Therefore, this work assessed the antidiabetic action of n-butanol extract from the whole plant Atractylis flava Desf (BEAF). These ethnomedicinal properties of BEAF were scientifically validated using in vitro and in vivo assays. In vitro antidiabetic effect of the BEAF was conducted using α-Glucosidase and α-Amylase assays. While the antihyperglycemic activity was assessed using two rat models: Alloxan-induced diabetic rats and oral glucose challenged rats. Experimental diabetes was induced by a single intraperitoneal injection of alloxan at a dose of 150 mg/kg and animals with fasting blood glucose levels (BGL) > 200 mg/dL were considered diabetic. Glibenclamide (5 mg/kg) was used as a typical drug.

Results

The BEAF at all tested dose levels (100, 250, and 500 mg/kg) showed a significant decrease in blood glucose level in all the two animal models. Besides, the plant extract exhibited a potent inhibitory effect on α-Amylase and α-Glucosidase activity at a concentration of 1000 µg/mL with 76.17% and 89.37%, respectively.

Conclusion

BEAF exerts in vitro and in vivo antidiabetic effects, these results suggest that the plant extract can be a therapeutic resource in the treatment of diabetes and hyperlipidemia.

Background

Diabetes mellitus is a serious complex multifactorial disorder that imposes huge health and economic burden on societies. Because the currently available medications have many drawbacks, it's important to look for alternative therapies. Medicinal plants utilized in folk medicine are ideal candidates. Therefore, this work assessed the antidiabetic action of n-butanol extract from the whole plant Atractylis flava Desf (BEAF). These ethnomedicinal properties of BEAF were scientifically validated using in vitro and in vivo assays. In vitro antidiabetic effect of the BEAF was conducted using α-Glucosidase and α-Amylase assays. While the antihyperglycemic activity was assessed using two rat models: Alloxan-induced diabetic rats and oral glucose challenged rats. Experimental diabetes was induced by a single intraperitoneal injection of alloxan at a dose of 150 mg/kg and animals with fasting blood glucose levels (BGL) > 200 mg/dL were considered diabetic. Glibenclamide (5 mg/kg) was used as a typical drug.

Results

The BEAF at all tested dose levels (100, 250, and 500 mg/kg) showed a significant decrease in blood glucose level in all the two animal models. Besides, the plant extract exhibited a potent inhibitory effect on α-Amylase and α-Glucosidase activity at a concentration of 1000 µg/mL with 76.17% and 89.37%, respectively.

Conclusion

BEAF exerts in vitro and in vivo antidiabetic effects, these results suggest that the plant extract can be a therapeutic resource in the treatment of diabetes and hyperlipidemia.

Background

Diabetes mellitus is a serious complex multifactorial disorder that imposes huge health and economic burden on societies. Because the currently available medications have many drawbacks, it's important to look for alternative therapies. Medicinal plants utilized in folk medicine are ideal candidates. Therefore, this work assessed the antidiabetic action of n-butanol extract from the whole plant Atractylis flava Desf (BEAF). These ethnomedicinal properties of BEAF were scientifically validated using in vitro and in vivo assays. In vitro antidiabetic effect of the BEAF was conducted using α-Glucosidase and α-Amylase assays. While the antihyperglycemic activity was assessed using two rat models: Alloxan-induced diabetic rats and oral glucose challenged rats. Experimental diabetes was induced by a single intraperitoneal injection of alloxan at a dose of 150 mg/kg and animals with fasting blood glucose levels (BGL) > 200 mg/dL were considered diabetic. Glibenclamide (5 mg/kg) was used as a typical drug.

Results

The BEAF at all tested dose levels (100, 250, and 500 mg/kg) showed a significant decrease in blood glucose level in all the two animal models. Besides, the plant extract exhibited a potent inhibitory effect on α-Amylase and α-Glucosidase activity at a concentration of 1000 µg/mL with 76.17% and 89.37%, respectively.

Conclusion

BEAF exerts in vitro and in vivo antidiabetic effects, these results suggest that the plant extract can be a therapeutic resource in the treatment of diabetes and hyperlipidemia.

Background

Diabetes mellitus is a serious complex multifactorial disorder that imposes huge health and economic burden on societies. Because the currently available medications have many drawbacks, it's important to look for alternative therapies. Medicinal plants utilized in folk medicine are ideal candidates. Therefore, this work assessed the antidiabetic action of n-butanol extract from the whole plant Atractylis flava Desf (BEAF). These ethnomedicinal properties of BEAF were scientifically validated using in vitro and in vivo assays. In vitro antidiabetic effect of the BEAF was conducted using α-Glucosidase and α-Amylase assays. While the antihyperglycemic activity was assessed using two rat models: Alloxan-induced diabetic rats and oral glucose challenged rats. Experimental diabetes was induced by a single intraperitoneal injection of alloxan at a dose of 150 mg/kg and animals with fasting blood glucose levels (BGL) > 200 mg/dL were considered diabetic. Glibenclamide (5 mg/kg) was used as a typical drug.

Results

The BEAF at all tested dose levels (100, 250, and 500 mg/kg) showed a significant decrease in blood glucose level in all the two animal models. Besides, the plant extract exhibited a potent inhibitory effect on α-Amylase and α-Glucosidase activity at a concentration of 1000 µg/mL with 76.17% and 89.37%, respectively.

Conclusion

BEAF exerts in vitro and in vivo antidiabetic effects, these results suggest that the plant extract can be a therapeutic resource in the treatment of diabetes and hyperlipidemia.

Context: More than 500 Centaurea species compose the Asteraceae family, and most of the recent studies made on the species of this genus proved their pharmacological potential, especially to treat chronic illnesses. Aims: To evaluate for the first time the antioxidant, anti-inflammatory, neuroprotective and anti-microbial properties of the n-butanol (nBuOH) and ethyl acetate (EA) extracts of the aerial part of Centaurea tougourensis. Methods: The antioxidant activity was determined by ABTS, galvinoxyl radical, phenanthroline, and reducing power assays, while the antiinflammatory effects were assessed by heat-induced hemolysis and egg albumin denaturation assays. The neuroprotective activity was assessed against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and the anti-microbial activity by the agar disk diffusion method. Results: Both extracts possess a great antioxidant capacity, but it was considered higher in the n-BuOH extract with respective IC50 values of 8.04 ± 0.21 μg/mL in ABTS assay and 4.25 ± 0.6 μg/mL in GOR assay, while the A0.50 values were 4.46 ± 0.55 μg/mL in phenanthroline assay and 11.16 ± 0.64 μg/mL in reducing power assay. The n-BuOH extract also showed a remarkable anti-inflammatory activity with an EC50 of 120.81 ± 0.2 μg/mL in egg albumin denaturation assay and 154.15 ± 0.14 μg/mL in heat-induced hemolysis assay. The neuroprotective activity of the n-BuOH extract was very strong in both AChE and BChE inhibitory assays with respective IC50 values of 9.8 ± 0.62 μg/mL and 173.53 ± 0.04 μg/mL. EA extract was more active on microbial strains. Conclusions: These encouraging results showed once again the pharmacological potential of Centaurea species

Context: More than 500 Centaurea species compose the Asteraceae family, and most of the recent studies made on the species of this genus proved their pharmacological potential, especially to treat chronic illnesses. Aims: To evaluate for the first time the antioxidant, anti-inflammatory, neuroprotective and anti-microbial properties of the n-butanol (nBuOH) and ethyl acetate (EA) extracts of the aerial part of Centaurea tougourensis. Methods: The antioxidant activity was determined by ABTS, galvinoxyl radical, phenanthroline, and reducing power assays, while the antiinflammatory effects were assessed by heat-induced hemolysis and egg albumin denaturation assays. The neuroprotective activity was assessed against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and the anti-microbial activity by the agar disk diffusion method. Results: Both extracts possess a great antioxidant capacity, but it was considered higher in the n-BuOH extract with respective IC50 values of 8.04 ± 0.21 μg/mL in ABTS assay and 4.25 ± 0.6 μg/mL in GOR assay, while the A0.50 values were 4.46 ± 0.55 μg/mL in phenanthroline assay and 11.16 ± 0.64 μg/mL in reducing power assay. The n-BuOH extract also showed a remarkable anti-inflammatory activity with an EC50 of 120.81 ± 0.2 μg/mL in egg albumin denaturation assay and 154.15 ± 0.14 μg/mL in heat-induced hemolysis assay. The neuroprotective activity of the n-BuOH extract was very strong in both AChE and BChE inhibitory assays with respective IC50 values of 9.8 ± 0.62 μg/mL and 173.53 ± 0.04 μg/mL. EA extract was more active on microbial strains. Conclusions: These encouraging results showed once again the pharmacological potential of Centaurea species

Context: More than 500 Centaurea species compose the Asteraceae family, and most of the recent studies made on the species of this genus proved their pharmacological potential, especially to treat chronic illnesses. Aims: To evaluate for the first time the antioxidant, anti-inflammatory, neuroprotective and anti-microbial properties of the n-butanol (nBuOH) and ethyl acetate (EA) extracts of the aerial part of Centaurea tougourensis. Methods: The antioxidant activity was determined by ABTS, galvinoxyl radical, phenanthroline, and reducing power assays, while the antiinflammatory effects were assessed by heat-induced hemolysis and egg albumin denaturation assays. The neuroprotective activity was assessed against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and the anti-microbial activity by the agar disk diffusion method. Results: Both extracts possess a great antioxidant capacity, but it was considered higher in the n-BuOH extract with respective IC50 values of 8.04 ± 0.21 μg/mL in ABTS assay and 4.25 ± 0.6 μg/mL in GOR assay, while the A0.50 values were 4.46 ± 0.55 μg/mL in phenanthroline assay and 11.16 ± 0.64 μg/mL in reducing power assay. The n-BuOH extract also showed a remarkable anti-inflammatory activity with an EC50 of 120.81 ± 0.2 μg/mL in egg albumin denaturation assay and 154.15 ± 0.14 μg/mL in heat-induced hemolysis assay. The neuroprotective activity of the n-BuOH extract was very strong in both AChE and BChE inhibitory assays with respective IC50 values of 9.8 ± 0.62 μg/mL and 173.53 ± 0.04 μg/mL. EA extract was more active on microbial strains. Conclusions: These encouraging results showed once again the pharmacological potential of Centaurea species

Context: More than 500 Centaurea species compose the Asteraceae family, and most of the recent studies made on the species of this genus proved their pharmacological potential, especially to treat chronic illnesses. Aims: To evaluate for the first time the antioxidant, anti-inflammatory, neuroprotective and anti-microbial properties of the n-butanol (nBuOH) and ethyl acetate (EA) extracts of the aerial part of Centaurea tougourensis. Methods: The antioxidant activity was determined by ABTS, galvinoxyl radical, phenanthroline, and reducing power assays, while the antiinflammatory effects were assessed by heat-induced hemolysis and egg albumin denaturation assays. The neuroprotective activity was assessed against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and the anti-microbial activity by the agar disk diffusion method. Results: Both extracts possess a great antioxidant capacity, but it was considered higher in the n-BuOH extract with respective IC50 values of 8.04 ± 0.21 μg/mL in ABTS assay and 4.25 ± 0.6 μg/mL in GOR assay, while the A0.50 values were 4.46 ± 0.55 μg/mL in phenanthroline assay and 11.16 ± 0.64 μg/mL in reducing power assay. The n-BuOH extract also showed a remarkable anti-inflammatory activity with an EC50 of 120.81 ± 0.2 μg/mL in egg albumin denaturation assay and 154.15 ± 0.14 μg/mL in heat-induced hemolysis assay. The neuroprotective activity of the n-BuOH extract was very strong in both AChE and BChE inhibitory assays with respective IC50 values of 9.8 ± 0.62 μg/mL and 173.53 ± 0.04 μg/mL. EA extract was more active on microbial strains. Conclusions: These encouraging results showed once again the pharmacological potential of Centaurea species

Context: More than 500 Centaurea species compose the Asteraceae family, and most of the recent studies made on the species of this genus proved their pharmacological potential, especially to treat chronic illnesses. Aims: To evaluate for the first time the antioxidant, anti-inflammatory, neuroprotective and anti-microbial properties of the n-butanol (nBuOH) and ethyl acetate (EA) extracts of the aerial part of Centaurea tougourensis. Methods: The antioxidant activity was determined by ABTS, galvinoxyl radical, phenanthroline, and reducing power assays, while the antiinflammatory effects were assessed by heat-induced hemolysis and egg albumin denaturation assays. The neuroprotective activity was assessed against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and the anti-microbial activity by the agar disk diffusion method. Results: Both extracts possess a great antioxidant capacity, but it was considered higher in the n-BuOH extract with respective IC50 values of 8.04 ± 0.21 μg/mL in ABTS assay and 4.25 ± 0.6 μg/mL in GOR assay, while the A0.50 values were 4.46 ± 0.55 μg/mL in phenanthroline assay and 11.16 ± 0.64 μg/mL in reducing power assay. The n-BuOH extract also showed a remarkable anti-inflammatory activity with an EC50 of 120.81 ± 0.2 μg/mL in egg albumin denaturation assay and 154.15 ± 0.14 μg/mL in heat-induced hemolysis assay. The neuroprotective activity of the n-BuOH extract was very strong in both AChE and BChE inhibitory assays with respective IC50 values of 9.8 ± 0.62 μg/mL and 173.53 ± 0.04 μg/mL. EA extract was more active on microbial strains. Conclusions: These encouraging results showed once again the pharmacological potential of Centaurea species

The short circuit is among one of the most dangerous electrical faults in induction motors, which leads to serious implications on the motor operation and its performance. The present paper deals with the influence of the stator short circuit fault in its early stage in terms of performances and service continuity of an electric vehicle (EV) using a dual induction motor’s structure piloted by Backstepping control. An equivalent induction motor model with turn-to-turn fault on one stator phase, without already assuming the temperature effect through an intrinsic model, is investigated and thereafter its impacts on electric vehicle performance using simulation tests are presented and discussed.

Managing software architecture represents a big challenge throughout the development lifecycle. The complexity of the involved structural elements and the relations among them make the specified models look oversized and fuzzy, which makes the architecture incomprehensible, hard to maintain, and difficult to assess its quality. This paper's goal is to propose a powerful methodology for simplifying and reducing models' complexity to increase understandability, smoothing maintenance, and facilitating architecture monitoring and assessment. For this purpose, the authors rely heavily on two major concepts, multi-view modeling, and incremental model projection. The multi-viewing requires that all models must have two main views to describe the architecture and the mapping to its relevant quality attributes. The incremental projection is a methodology used to specialize and minimize models progressively to make them simpler and clearer. The results show that projecting models incrementally can reduce and narrow them significantly.

Managing software architecture represents a big challenge throughout the development lifecycle. The complexity of the involved structural elements and the relations among them make the specified models look oversized and fuzzy, which makes the architecture incomprehensible, hard to maintain, and difficult to assess its quality. This paper's goal is to propose a powerful methodology for simplifying and reducing models' complexity to increase understandability, smoothing maintenance, and facilitating architecture monitoring and assessment. For this purpose, the authors rely heavily on two major concepts, multi-view modeling, and incremental model projection. The multi-viewing requires that all models must have two main views to describe the architecture and the mapping to its relevant quality attributes. The incremental projection is a methodology used to specialize and minimize models progressively to make them simpler and clearer. The results show that projecting models incrementally can reduce and narrow them significantly.

Managing software architecture represents a big challenge throughout the development lifecycle. The complexity of the involved structural elements and the relations among them make the specified models look oversized and fuzzy, which makes the architecture incomprehensible, hard to maintain, and difficult to assess its quality. This paper's goal is to propose a powerful methodology for simplifying and reducing models' complexity to increase understandability, smoothing maintenance, and facilitating architecture monitoring and assessment. For this purpose, the authors rely heavily on two major concepts, multi-view modeling, and incremental model projection. The multi-viewing requires that all models must have two main views to describe the architecture and the mapping to its relevant quality attributes. The incremental projection is a methodology used to specialize and minimize models progressively to make them simpler and clearer. The results show that projecting models incrementally can reduce and narrow them significantly.

Studying the influence of climate variability indices on extreme precipitation will help to understand the variability of extreme precipitation. However, the influence of climate indices on extreme precipitation over the world has received little attention. In this work, a stationary generalized extreme value (GEV) model and nonstationary GEV models on the annual maximum 1-day precipitation (Rx1day) at the global scale are developed. The Bayesian framework is adopted in this study. Four climate variability indices such as the El Niño-Southern Oscillation (ENSO), Atlantic Multidecadal Oscillation (AMO), North Atlantic Oscillation (NAO) and Pacific Decadal Oscillation (PDO) are used independently as covariates. The results showed that nonstationary GEV models are preferred over the stationary GEV model based on Deviance Information Criterion (DIC) and the significant covariates for a large number of grid cells which indicates that the influence of climate index is not a negligible component in the GEV model. In addition, the positive and negative influences of the covariates are analyzed. At the global, the effect of ENSO on the location parameter is greater than the effect of the other covariates, indicating that ENSO has a strong influence on extreme precipitation in large parts of the world.

Studying the influence of climate variability indices on extreme precipitation will help to understand the variability of extreme precipitation. However, the influence of climate indices on extreme precipitation over the world has received little attention. In this work, a stationary generalized extreme value (GEV) model and nonstationary GEV models on the annual maximum 1-day precipitation (Rx1day) at the global scale are developed. The Bayesian framework is adopted in this study. Four climate variability indices such as the El Niño-Southern Oscillation (ENSO), Atlantic Multidecadal Oscillation (AMO), North Atlantic Oscillation (NAO) and Pacific Decadal Oscillation (PDO) are used independently as covariates. The results showed that nonstationary GEV models are preferred over the stationary GEV model based on Deviance Information Criterion (DIC) and the significant covariates for a large number of grid cells which indicates that the influence of climate index is not a negligible component in the GEV model. In addition, the positive and negative influences of the covariates are analyzed. At the global, the effect of ENSO on the location parameter is greater than the effect of the other covariates, indicating that ENSO has a strong influence on extreme precipitation in large parts of the world.

With the evolution of the internet of things (IoT), and due to its significant need in the industry, Industrial IoT (IIoT) becomes the suitable naming for this accompaniment. IIoT changed the view of the industry intelligently and over the internet. This overlapping of IoT and industry requires special treatment when systems deal with heterogeneous devices in a distributed environment and complex tasks. In this paper, we propose a middleware solution based on multi-agents system (MAS) to handle the distributed control of complex systems autonomously in an industrial environment. The proposed middleware enables machine-to-machine (M2M) communications among the system's components. In this work, we also addressed the distributed diagnostic for real industrial system using MAS with a new suitable communication strategy to support the heterogeneity and interoperability issued in IIoT and assure real-time monitoring and control. Finally, we present a qualitative evaluation of our solution on real case study (cement factory).

With the evolution of the internet of things (IoT), and due to its significant need in the industry, Industrial IoT (IIoT) becomes the suitable naming for this accompaniment. IIoT changed the view of the industry intelligently and over the internet. This overlapping of IoT and industry requires special treatment when systems deal with heterogeneous devices in a distributed environment and complex tasks. In this paper, we propose a middleware solution based on multi-agents system (MAS) to handle the distributed control of complex systems autonomously in an industrial environment. The proposed middleware enables machine-to-machine (M2M) communications among the system's components. In this work, we also addressed the distributed diagnostic for real industrial system using MAS with a new suitable communication strategy to support the heterogeneity and interoperability issued in IIoT and assure real-time monitoring and control. Finally, we present a qualitative evaluation of our solution on real case study (cement factory).

With the evolution of the internet of things (IoT), and due to its significant need in the industry, Industrial IoT (IIoT) becomes the suitable naming for this accompaniment. IIoT changed the view of the industry intelligently and over the internet. This overlapping of IoT and industry requires special treatment when systems deal with heterogeneous devices in a distributed environment and complex tasks. In this paper, we propose a middleware solution based on multi-agents system (MAS) to handle the distributed control of complex systems autonomously in an industrial environment. The proposed middleware enables machine-to-machine (M2M) communications among the system's components. In this work, we also addressed the distributed diagnostic for real industrial system using MAS with a new suitable communication strategy to support the heterogeneity and interoperability issued in IIoT and assure real-time monitoring and control. Finally, we present a qualitative evaluation of our solution on real case study (cement factory).

With the evolution of the internet of things (IoT), and due to its significant need in the industry, Industrial IoT (IIoT) becomes the suitable naming for this accompaniment. IIoT changed the view of the industry intelligently and over the internet. This overlapping of IoT and industry requires special treatment when systems deal with heterogeneous devices in a distributed environment and complex tasks. In this paper, we propose a middleware solution based on multi-agents system (MAS) to handle the distributed control of complex systems autonomously in an industrial environment. The proposed middleware enables machine-to-machine (M2M) communications among the system's components. In this work, we also addressed the distributed diagnostic for real industrial system using MAS with a new suitable communication strategy to support the heterogeneity and interoperability issued in IIoT and assure real-time monitoring and control. Finally, we present a qualitative evaluation of our solution on real case study (cement factory).

This paper deals with the analysis of the inelastic response of buildings originally damaged by earthquakes and subjected to earthquake aftershock and wind loading. The overall aim is to establish the effect of wind actions on structural stability. To that end, one four-story bare frame benchmarked by the European Laboratory for Structural Assessment, is subject to various levels of winds and earthquake joint load while monitoring changes on the ductility demand. In this paper is shown that the combined action of strong winds and earthquakes, however its low probability of occurrence, would cause a decrease of strength reduction factors and considerably increase the ductility demand of damaged infrastructure hence inducing additional risks that would otherwise remain unquantified. The paper examines the non-linear performance of Multi-degree of freedom systems subject to various levels of winds and earthquake load and deals with the estimation of strength reduction factors. This is a relatively unexplored area of research which builds on past developments whereby inelastic performance of buildings has been discussed. It also links to various other paths of development such as structural reliability, forensic and control systems engineering.