@article {62570,
	title = {In vitro, acute and subchronic evaluation of the antidiabetic activity of Atractylis flava Desf n-butanol extract in alloxan-diabetic rats},
	journal = {Future Journal of Pharmaceutical Sciences},
	volume = {7},
	year = {2021},
	month = {2021},
	pages = {1-7},
	abstract = {
	Background



	Diabetes mellitus is a serious complex multifactorial disorder that imposes huge health and economic burden on societies. Because the currently available medications have many drawbacks, it{\textquoteright}s important to look for alternative therapies. Medicinal plants utilized in folk medicine are ideal candidates. Therefore, this work assessed the antidiabetic action of\&nbsp;n-butanol extract from the whole plant\&nbsp;Atractylis\&nbsp;flava Desf\&nbsp;(BEAF). These ethnomedicinal properties of BEAF were scientifically validated using\&nbsp;in vitro\&nbsp;and\&nbsp;in vivo\&nbsp;assays. In vitro antidiabetic effect of the BEAF was conducted using α-Glucosidase and α-Amylase assays. While the antihyperglycemic activity was assessed using two rat models: Alloxan-induced diabetic rats and oral glucose challenged rats. Experimental diabetes was induced by a single intraperitoneal injection of alloxan at a dose of 150\&nbsp;mg/kg and animals with fasting blood glucose levels (BGL) \&gt; 200\&nbsp;mg/dL were considered diabetic. Glibenclamide (5\&nbsp;mg/kg) was used as a typical drug.



	Results



	The BEAF at all tested dose levels (100, 250, and 500\&nbsp;mg/kg) showed a significant decrease in blood glucose level in all the two animal models. Besides, the plant extract exhibited a potent inhibitory effect on α-Amylase and α-Glucosidase activity at a concentration of 1000\&nbsp;{\textmu}g/mL with 76.17\% and 89.37\%, respectively.



	Conclusion



	BEAF exerts\&nbsp;in vitro\&nbsp;and\&nbsp;in vivo\&nbsp;antidiabetic effects, these results suggest that the plant extract can be a therapeutic resource in the treatment of diabetes and hyperlipidemia.

},
	isbn = {2314-7253},
	url = {https://fjps.springeropen.com/articles/10.1186/s43094-021-00358-5},
	author = {Melakhessou, Mohamed-Akram and Marref, Salah-Eddine and Benkiki, Naima and Marref, Cherine and Becheker, Imene and Khattabi, Latifa}
}
