@article {62647,
	title = {ZINC ALLEVIATES POTASSIUM DICHROMATE-INDUCED HEPATOTOXICITY IN PREGNANT WISTAR RATS},
	journal = {Malaysian Journal Of Biochemistry \& Molecular BiologyMalaysian Journal Of Biochemistry \& Molecular Biology},
	volume = {2},
	year = {2021},
	month = {2021},
	pages = {10-16},
	abstract = {The present study aimed to investigate the potential protective effects of zinc (Zn) against hexavalent chromium-induced hepatotoxicity in pregnant Wistar rats. Female rats were treated subcutaneously (s.c) on the 3 rd day of pregnancy, with NaCl 0.9 \% and served as control, K2Cr2O7 (10 mg/kg bw) alone, or K2Cr2O7 in association with ZnCl2 (20 mg/kg bw). Hepatic biochemical parameters, oxidative stress biomarkers and DNA damage were monitored. Results revealed that K2Cr2O7 disturbed plasma ALT, AST, ALP and GGT, induced hepatic oxidative stress and DNA fragmentation. The co-treatment with Zn has alleviated K2Cr2O7-induced hepatotoxicity by exhibiting antioxidant and genoprotective effects in pregnant Wistar rats.},
	author = {Fedala, Anfal and Ounassa, ADJROUD and Saouli, Asma and Imane, Salah}
}
