@article {62672,
	title = {Anti-inflammatory and hemostatic effects of Linaria reflexa Desf},
	journal = {Natural Product Research},
	volume = {35},
	number = {16},
	year = {2021},
	month = {2021},
	pages = {2778-2783},
	abstract = {
	The work presented here was aimed to investigate the\&nbsp;in vivo\&nbsp;anti-inflammatory and\&nbsp;in vitro\&nbsp;hemostatic activities of\&nbsp;Linaria reflexa\&nbsp;extract and to establish the relationship between its bioactivity and chemical composition. Twenty-three secondary metabolites were identified, most of them are good anti-inflammatory agents, in line with data by carrageenin-induced rat paw edema assays of the\&nbsp;n-butanol extract showing high anti-inflammatory inhibition (63.90\%) of edema swelling in the rat paw at the dose 200 mg/kg after 4 h. Furthermore, both extent of inflammatory response and tissue injury were prevented keeping the levels of rate myeloperoxidase (60.16\%) and of malondialdehyde, which is the final product of lipid peroxidation generated by free radicals (58.58\%). The same extract showed also a remarkable hemostatic effect established by measuring the coagulation time of decalcified plasma (45 s), related to its flavonoid glycosides content.

},
	isbn = {1478-6419},
	url = {https://pubmed.ncbi.nlm.nih.gov/31507213/},
	author = {Cheriet, Thamere and HANFER, Mourad and Mancini, Ines and Benelhadj, Samiha and Laouas, Nour Essabah and Ameddah, Souad and Menad, Ahmed and Seghiri, Ramdane}
}
