@article {62718,
	title = {Evidence of anti-inflammatory and anti-ulcer properties of aerial parts of Centaurea tougourensis Boiss. and Reut},
	journal = {Tropical Journal of Pharmaceutical Research},
	volume = {20},
	number = {8},
	year = {2021},
	month = {2021},
	abstract = {
	Purpose:\&nbsp;To determine the anti-inflammatory and anti-ulcer properties of the aerial parts of\&nbsp;Centaurea tougourensis\&nbsp;Boiss. \&amp; Reut.



	\&nbsp;



	Methods:\&nbsp;The effects of n-butanol (n-BuOH) extract of the aerial part of\&nbsp;Centaurea tougourensis\&nbsp;on carrageenan-induced paw edema and ethanol-induced gastric mucosal damage were determined at 2 doses (200 and 400 mg/kg, po) in a mouse model. For each test, the animals were randomly divided into negative and positive control groups, as well as extract-treated groups. The mice were observed for any sign of inflammation for a period of 24h.



	\&nbsp;



	Results:\&nbsp;Reduction of paw edema by\&nbsp;C. tougourensis\&nbsp;extract was highly significant (p \&lt; 0.001) at a dose of 400 mg/kg 24 h after carrageenan injection, with 55.26 \% inhibition, followed very closely by 53.15 \% inhibition at the dose of 200 mg/kg; indomethacin group showed an inhibition of 60 \%. Histological examination supported the inhibition results. A significant reduction in inflammation by the extract at a dose of 400 mg/kg was also observed. No sign of ulcer was observed with\&nbsp;C. tougourensis\&nbsp;at the two doses (200 and 400 mg/kg). The total polyphenol content of the n-BuOH extract was 85.44 цg gallic acid equivalent/mg of extract. Tannins were the most abundant fraction (51.87 цg tannic acid equivalent/mg of extract), followed by flavonoids (25.55 цg quercetin equivalent/mg of extract).



	\&nbsp;



	Conclusion:\&nbsp;The results indicate that\&nbsp;C. tougourensis\&nbsp;may have potential beneficial effects in the treatment of diseases associated with inflammation and pain, besides its protective effect on the gastrointestinal tract.

},
	isbn = {1596-5996},
	url = {https://www.ajol.info/index.php/tjpr/article/view/221659},
	author = {Bensaad ,Mohamed-Sabri and Dassamiour, Saliha and Hambaba, Leila and Kahoul, Mohamed-Amine and Benhoula, Mohammed}
}
