@article {8087,
	title = {Phytochemical screening, antioxidant properties, and photo-protective activities of Salvia balansae de No{\'e} ex Coss},
	journal = {Open Chemistry},
	volume = {22},
	year = {2024},
	pages = {1-18},
	abstract = {The present study evaluated the potential of\&nbsp;Salvia balansae\&nbsp;from the Aures Mountains as a source of natural bioactive compounds. Leaves, flowers, and stems were extracted separately using methanol, ethanol, and acetone. Phenolic compounds were quantified colorimetrically and identified using liquid chromatography coupled with mass spectrometry (LC-MS). Antioxidant capacity was assessed using six different\&nbsp;in vitro\&nbsp;assays, 2,2{\textquoteright}-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, 1,1-diphenyl-1-picrylhydrazyl, cupric reducing antioxidant capacity, ferric reducing antioxidant power, ferrous ion chelating, and phenanthroline assay, while the photo-protective capacity was evaluated using the sun protective factor. The methanolic flower extracts revealed the highest O-diphenol and phenolic levels (287.9 {\textpm} 0.50 and 147.87 {\textpm} 0.21 {\textmu}g GAE/mg, respectively), whereas the acetonic and ethanolic leaf extracts contained the highest flavonoid (72.17 {\textpm} 0.12 μg QE/mg) and flavonol (35.28 {\textpm} 0.05 μg QE/mg) levels, respectively. LC-MS was used to identify 18 phenolics, including quinic acid (5.051{\textendash}69.69 ppm), luteolin-7-o-glucoside (7.802{\textendash}44.917 ppm), apigenin-7-o-glucoside (3.751{\textendash}68.507 ppm), and cirsiliol (2.081{\textendash}15.608 ppm), distinguishing this Aures taxon. Principal component analysis and unweighted pair-group method with arithmetic mean revealed variability in phytochemicals, antioxidant properties, and photo-protective activity influenced by biological activities and the compound content. Overall,\&nbsp;S. balansae\&nbsp;demonstrated promising photo-protective capacity, the presence of key bioactive compounds, and wide-ranging antioxidant potential, presenting this endemic plant as a valuable source of natural antioxidants and photo-protective agents with pharmaceutical and cosmetic applications.},
	url = {https://doi.org/10.1515/chem-2024-0024},
	author = {Bendrihem, Khadra-Afaf and Zeraib , Azzeddine and Atoki, Ayomide-Victor and Mihoubi, Mohamed-Aim{\`e}ne and Kadi, Kenza and Bensuici, Chawki and Hachemi, Messaoud and Ayeb, Nour-Elhouda and Messaoudi, Mohammed}
}
