@article {8082,
	title = {Antihyperglycemic Potential of Methanolic Extracts from the Medicinal Plants: Marrubium deserti De No{\'e} and Marrubium vulgare L.},
	journal = {International Journal of Pharmacology},
	volume = {207},
	number = {2},
	year = {2024},
	pages = {269-278.},
	abstract = {Background and Objective: Plants of the genusMarrubium are used to cure several infectious diseases like asthma, rheumatoid and diabetes.This study investigatedin vivo antihyperglycemic capacity of the methanolic fraction (MeOHE) of twoMarrubium species via animal model.Materials and Methods: The plant extracts were investigated both qualitatively and quantitatively to reveal their phytochemical composition.Pharmacologically speaking, Wistar albino rats of either sex (150-180 g) were used to investigate the antidiabetic effect using 25 rats in each ofthe two used approaches; respectively Oral Glucose Tolerance Test (OGTT) and streptozotocin-induced diabetes approaches. In addition, variousbiochemical parameters were investigated to confirm the pharmacological quality of our plants. Evaluated for their possible antidiabetic effectduring two consecutive weeks for glycemia levels (2 hrs period). Results: Data revealed that MeOHE induced a significant antihyperglycemic effect,in whichM. deserti, a slight decrease in the glucose level at (143{\textpm}0.5 mg/dL) was obtained while a reduction was recorded forM. vulgare(71.5{\textpm}0.75 mg/dL) with a same observation for triglycerides, cholesterol, glutamic-oxaloacetic transaminase (TGO), glutamic pyruvic transaminase(TGP), creatinine comparing to standard. Moreover, the result showed high levels of phenolic and flavono{\"{\i}ds content. Conclusion: This modestwork confirmed once again the real pharmacological capacity of vegetals and their possible implication to cure diabetes and complications relatedto it underlying the antihyperglycemic activity of these plants.},
	url = {https://doi.org/10.3923/ijp.2024.269.278},
	author = {Ghedadba, Nabil and Hambaba, Leila and Bensaad ,Mohamed-Sabri and Dassamiour, Saliha}
}
