@article {61528,
	title = {Effets ut{\'e}roactivateur et analg{\'e}sique d\&$\#$39;un inhibiteur d\&$\#$39;enk{\'e}phalinase pendant la p{\'e}riode pr{\'e}parturiente},
	year = {Submitted},
	author = {Clabaut, Monique and Adjroud, Ounassa}
}
@article {62487,
	title = {Nephroprotective Efficacy of Selenium and Zinc Against Potassium Dichromate-Induced Renal Toxicity in Pregnant Wistar Albino Rats},
	journal = {Biological Trace Element Research},
	year = {2022},
	month = {2022},
	pages = {1-13},
	abstract = {
	Hexavalent chromium (CrVI) compounds are potent toxicants commonly used in numerous industries. Thus, potential toxic effects and health hazards are of high relevance. Selenium (Se) and zinc (Zn) are known for their antioxidant and chemoprotective properties. However, little is known about their protective effects against CrVI-induced renal damage during pregnancy. In this context, the present study aimed to investigate the protective efficacy of these two essential elements against potassium dichromate-induced nephrotoxicity in pregnant\&nbsp;Wistar Albino\&nbsp;rats. Female rats were divided into control and four treated groups of six each receiving subcutaneously on the 3rd day of pregnancy, K2Cr2O7\&nbsp;(10\&nbsp;mg/kg, s.c. single dose) alone, or in association with Se (0.3\&nbsp;mg/kg, s.c. single dose), ZnCl2\&nbsp;(20\&nbsp;mg/kg, s.c. single dose) or both of them simultaneously. The nephrotoxic effects were monitored by the evaluation of plasma renal parameters, oxidative stress biomarkers, DNA damage, and renal Cr content. The obtained results showed that K2Cr2O7\&nbsp;disturbed renal biochemical markers, induced oxidative stress and DNA fragmentation in kidney tissues, and altered renal histoarchitecture. The co-administration of Se and/or ZnCl2\&nbsp;has exhibited pronounced chelative, antioxidant, and genoprotective effects against K2Cr2O7-induced renal damage and attenuated partially the histopathological alterations. These results suggest that Se and Zn can be used as efficient nephroprotective agents against K2Cr2O7-induced toxicity in pregnant\&nbsp;Wistar Albino\&nbsp;rats.

},
	isbn = {1559-0720},
	url = {https://link.springer.com/article/10.1007/s12011-021-03069-3},
	author = {Fedala, Anfal and Adjroud, Ounassa and Bennoune, Omar and Abid-Essefi, Salwa and Foughalia, Abdelhamid and Timoumi, Rim}
}
@article {62529,
	title = {Protective Effects of Selenium and Zinc Against Nickel Chloride\&ndash;Induced Hormonal Changes and Oxidative Damage in Thyroid of Pregnant Rats},
	journal = {Biological Trace Element ResearchBiological Trace Element Research},
	volume = {155},
	year = {2021},
	month = {2021},
	abstract = {Nickel chloride (NiCl2) is a heavy metal that may affect the function of the thyroid. Selenium (Se) and zinc (Zn) are essential trace elements involved in thyroid hormone metabolism. However, little is reported about thyrotoxicity during gestation. The current study aimed to investigate the protective effects of selenium and zinc against NiCl2-induced thyrotoxicity in pregnant Wistar rats. Female rats were treated subcutaneously (s.c.) on the 3rd day of pregnancy, with NaCl 0.9\% and served as control, NiCl2\&nbsp;(100\&nbsp;mg/kg body weight (BW)) alone, or in association with Se (0.3\&nbsp;mg/kg, s.c.), ZnCl2\&nbsp;(20\&nbsp;mg/kg, s.c.), or both of them simultaneously. Oxidative stress parameters, thyroid biomarkers, and histopathological examination were evaluated. Results showed that NiCl2\&nbsp;exposure caused a significant decrease in maternal body weight and an increase in absolute and relative thyroid weight compared to the controls. NiCl2\&nbsp;administration also led to decreased plasma triiodothyronine (T3) and thyroxine (T4) with a concomitant significant increase in thyroid-stimulating hormone (TSH) levels when compared to that of control. In addition, an overall pro-oxidant effect was associated with a decrease in the reduced glutathione (GSH) and nonprotein thiol (NPSH) contents and the enzymatic activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD), and an increase in malondialdehyde (MDA). These biochemical disturbances were confirmed by histological changes. However, the co-treatment of Se and/or ZnCl2\&nbsp;attenuates NiCl2-induced changes. Our findings suggested that Se and ZnCl2\&nbsp;ameliorated NiCl2-induced thyrotoxicity in pregnant Wistar rats by exhibiting antioxidant effects.},
	author = {Salah, Imane and Adjroud, Ounassa and Elwej, Awatef}
}
@article {62528,
	title = {Protective effects of selenium and zinc against nickel chloride{\textendash}induced hormonal changes and oxidative damage in thyroid of pregnant rats},
	journal = {Biological Trace Element ResearchBiological Trace Element Research},
	year = {2021},
	month = {2021},
	pages = {1-12},
	isbn = {1559-0720},
	author = {Salah, Imane and Adjroud, Ounassa and Elwej, Awatef}
}
@article {62648,
	title = {Protective effects of selenium and zinc against potassium dichromate{\textendash}induced thyroid disruption, oxidative stress, and DNA damage in pregnant Wistar rats},
	journal = {Environmental Science and Pollution ResearchEnvironmental Science and Pollution Research},
	volume = {28},
	year = {2021},
	month = {2021},
	pages = {22563-22576},
	isbn = {1614-7499},
	author = {Fedala, Anfal and Adjroud, Ounassa and Abid-Essefi, Salwa and Timoumi, Rim}
}
@article {62649,
	title = {Protective effects of selenium and zinc against potassium dichromate\&ndash;induced thyroid disruption, oxidative stress, and DNA damage in pregnant Wistar rats},
	journal = {Environmental Science and Pollution ResearchEnvironmental Science and Pollution Research},
	volume = {28},
	year = {2021},
	month = {2021},
	pages = {22563{\textendash}22576},
	abstract = {Hexavalent chromium (CrVI) is an environmental pollutant and an endocrine-disrupting metal. Se and Zn are essential trace elements, known to play a crucial role in thyroid homeostasis. However, there is a lack of data reporting thyrotoxicity during gestation. In this study, we investigated the protective effects of selenium and zinc against potassium dichromate{\textendash}induced thyrotoxicity in pregnant Wistar rats. Thirty pregnant Wistar rats were divided into control and four treated groups receiving subcutaneously (s.c) on the 3rd day of pregnancy, K2Cr2O7\&nbsp;(10 mg/kg, s.c) alone, or in association with Se (0.3 mg/kg, s.c), ZnCl2\&nbsp;(20 mg/kg, s.c), or both of them simultaneously. The hormonal profile, oxidative stress biomarkers, DNA damage, and histological modifications were evaluated. Our main findings showed that K2Cr2O7\&nbsp;promoted hypothyroidism, oxidative stress, genotoxicity, and histological alterations in the thyroid gland. The co-treatment with Se or ZnCl2\&nbsp;has mitigated K2Cr2O7-induced thyrotoxicity in pregnant Wistar rats by exhibiting antioxidant and genoprotective effects. However, the combined co-treatment of both of them was less thyroprotective, and therefore, further investigations on the synergetic interaction of Se and Zn against CrVI toxicity using different doses and exposure routes are required.},
	author = {Fedala, Anfal and Adjroud, Ounassa and Abid-Essefi, Salwa and Timoumi, Rim}
}
@article {63089,
	title = {PROTECTIVE EFFECTS OF SELENIUM AND ZINC ON NICKEL CHLORIDE INDUCED REPRODUCTIVE TOXICITY IN WISTAR ALBINOS PREIMPLANTED RATS},
	journal = {Studia Universitatis Vasile Goldis Seria Stiintele Vietii (Life Sciences )Studia Universitatis Vasile Goldis Seria Stiintele Vietii (Life Sciences )},
	volume = {30},
	year = {2020},
	month = {2020},
	pages = {126 - 135},
	abstract = {: The aim of this study was to investigate that nickel chloride (NiCl2) induced reproductive toxicity in pre- implanted Wistar Rats and examined the possible protective effect of zinc chloride and selenium on plasma concentration of the hormones of 17 b etradiol (E2) and progesterone (prog); on the reproductive organ{\textquoteright}s histology and on development. Experimental results showed the subcutaneous (s.c) administration of Nicl2 to Wistar albino Rats induced a decrease in plasma concentration of E2 and prog in addition, disturbance in development parameters and structural damages to the histology of the reproductive organs. Conversely, Se and ZnCl2 dues to the antioxidants property, regulate the secretion of E2 and Prog hormones, prevent alterations in the reproductive organs and in development in preimplanted rates receiving NiCl2.},
	author = {BOULILA, Ismahene and Adjroud, Ounassa}
}
@proceedings {63568,
	title = {Evaluation de l\&rsquo;hepatotoxicite induite par le dichromate de potassium chez les rates gestantes de la souche albinos wistar},
	year = {2019},
	month = {2019},
	address = {Universit{\'e} Mostefa BEN BOULAID- Batna 2, Alg{\'e}rie},
	author = {Anfal, Fedala and Adjroud, Ounassa and Saouli, Asma}
}
@proceedings {64554,
	title = {L\&rsquo;effet du nickel administr{\'e} par voie sous cutan{\'e}e et son {\'e}ventuelle interaction avec le s{\'e}l{\'e}nium et le zinc sur la leucopo{\"\i}{\`e}se et l\&rsquo;histologie h{\'e}patique},
	journal = {6{\`e}mes Journ{\'e}es Scientifiques de l{\textquoteright}Association Tunisienne de Toxicologie(ATT). 21 -23 Janvier},
	year = {2017},
	month = {2017},
	address = {TABERKA ,TUNISIE},
	author = {Fedala, Anfal and Adjroud, Ounassa}
}
@proceedings {64575,
	title = {Selenium Administration Can Alter Some Biochemical Parameters in Rats},
	journal = {HBSRA International Conference, Barcelona July 2017, 19th International Conference on Healthcare \& Life-Science Research (ICHLSR), 28-29 July 2017},
	year = {2017},
	month = {2017},
	address = {Barcelona, SPAIN},
	abstract = {
	Selenium (Se), an essential micronutrient of several major metabolic pathways, including thyroid hormone metabolism, antioxidant defense systems, and immune function becomes toxic to animal when it is elevated above a threshold concentration. The aim of the present study was to determine the effect of selenium in rats Wistar albino on plasma levels of cholesterol, triglycerides, urea, uric acid, albumin and calcium. The experimental groups received subcutaneously graded doses of Selenium (0.3 and 0.5 mg/kg, BW) for a period of 21 days and plasma biochemical parameters were evaluated after 3, 6 and 21 days. The results indicated that the graded doses of Selenium significantly decreased both the calcium and plasma cholesterol level during short-term and long-term respectively. On the other hand, Se elevated significantly the levels of plasma urea by 104\% after the first three days, uric acid by 126\%, on day 6 and triglycerides by 120\% on day 21. Whereas, the higher dose increased the level of plasma urea only on day 21 by 67\%. Furthermore, 0.5 mg s.c provoked an immediate and a significant increase in plasma cholesterol level by 47\% and in uric acid by 60\% during the first three days after treatment. Doses of Se augmented significantly on day 6, the level of plasma albumin by 85\% and 52 \% respectively. The results of the current study suggested that selenium alters the plasma biochemical parameters in rats. Keywords: Albumin, calcium, cholesterol, selenium, triglyceride, urea. uric acid

},
	url = {https://www.researchgate.net/publication/332223078_Selenium_Administration_Can_Alter_Some_Biochemical_Parameters_in_Rats},
	author = {Adjroud, Ounassa}
}
@proceedings {65422,
	title = {Effets de l\&$\#$39;administration par voie sous- cutan{\'e}e du nickel associe avec le zinc et le selenium sur l\&$\#$39;uremie et le determinisme de la reproduction chez les rates gestantes},
	journal = {Premier colloque International de Toxicologie et Sant{\'e}. 28-29 novembre},
	year = {2016},
	month = {2016},
	address = {GUELMA, ALGERIE},
	author = {Salah, Imane and Adjroud, Ounassa and BOULILA, Ismahene and Fedala, Anfal and Saouli, Asma}
}
@proceedings {65665,
	title = {Hexavalent Chromium-induced Changes in Biochemical Parameters of Wistar Albino Rats},
	journal = {International Conference on Biological and Chemical Processes (ICBCP), 25-26 April},
	year = {2016},
	month = {2016},
	address = {PARIS, FRANCE},
	abstract = {
	Potassium dichromate (K2Cr2O7) is one of the most toxic elements to which man can be exposed at work or in the environment. The purpose of the current work is to compare the effect of K2Cr2O7 using variations in the dose, route of administration and duration of exposure in male and female Wistar albino rats with a special focus on biochemical parameters. K2Cr2O7 was subcutaneously administered alone (10, 50 and 100 mg/kg body weight) to female Wistar albino rats. Male rats received in their drinking water K2Cr2O7 30 mg/L/day) for 20 consecutive days. The Biochemical parameters were evaluated on days 3, 6 and 21 after subcutaneous (sc.) treatment in female rats and on days 10 and 20 after oral administration in male rats. The subcutaneous (s.c.) administration of 25 mg/kg of K2Cr2O7 to Wistar albino rats induced a slight change in plasma glucose levels during the experiment period. On the contrary, a significant decrease in plasma glucose levels was observed with 50 mg/kg mainly on days 3 (-26\%) and 21 (-48\%) after treatment compared to controls females rats. On the other hand, the higher dose provoked a significant increase in plasma glucose concentrations on days 6 (+31\%) and 21 (+60\%). similarly, the lower dose of chromium had no effect on the plasma urea levels. Conversely, a significant increase (122\%) in this parameter was obtained during the first three days after treatment. In addition, a significant decrease in plasma glucose levels was observed with 50 mg/kg mainly on days 3 (-26\%) and 21 (-48\%) after treatment. On the other hand, the higher dose provoked a significant increase in plasma glucose concentrations on days 6 (+31\%) and 21 (+60\%). similarly, the lower dose of chromium had no effect on the plasma urea levels. Conversely, a significant increase in this parameter (122\%) was obtained during the first three days after treatment. In addition, administration of 100 mg/kg of K2Cr2O7 by s.c markedly augmented the levels of plasma urea on days 3 (62\%) and 6 (121\%). Administration of 30 mg/L/day of K2Cr2O7 in the drinking water induced a significant augmentation in both of plasma glucose (27\%) and urea (126\%) during the first ten days of treatment. These results suggested that K2Cr2O7 administered subcutaneously or in the drinking water may induce harmful effects on biochemical parameters. Keywords : glucose, potassium dichromate, Wistar albino rat, urea.

},
	author = {Adjroud, Ounassa}
}
@book {66072,
	title = {Interaction between NiCl2 and Selenium on Energy Profiles in Wistar albino Preimplanted Rats},
	year = {2015},
	month = {2015},
	address = {Venice, ITALY},
	author = {Adjroud, Ounassa}
}
@book {66459,
	title = {Influence de la vapeur de gazoline sur la modulation de certaines proteines pulmonaires chez le rat blanc.},
	year = {2014},
	month = {2014},
	address = {University of Oran 1, Algeria,},
	author = {Adjroud, Ounassa}
}
@book {66458,
	title = {Nephroprotective Effects of Selenium against Nickel Chloride-Induced Nephrotoxicity in Pregnant Rats},
	year = {2014},
	month = {2014},
	address = {Dubai, UAE},
	author = {Adjroud, Ounassa}
}
@article {66785,
	title = {The toxic effects of nickel chloride on liver, erythropoiesis, and development in Wistar albino preimplanted rats can be reversed with selenium pretreatment},
	journal = {Environmental toxicologyEnvironmental toxicology},
	volume = {28},
	year = {2013},
	month = {2013},
	pages = {290-298},
	abstract = {The exposure to nickel chloride (NiCl2) can cause hematotoxicity and hepatotoxicity and canaffect development. The present study pertains to the protective effect of selenium (Se) against NiCl2-induced toxicity in preimplanted\&nbsp;Wistar albino\&nbsp;rats. The subcutaneous (s.c.) administration of 25 or 50 mg/kg of NiCl2\&nbsp;to\&nbsp;Wistar albino\&nbsp;rats on day 3 of gestation induced an immediate and significant decrease in maternal body weight and anemia 2 days after treatment. In addition, an increase in plasma aspartate aminotransferase (AST) was observed. These effects were maintained on day 20 of gestation. Moreover, a significant increase in plasma alanine aminotransferase (ALT) levels was observed with the administration of 25 mg/kg of NiCl2. Conversely, administration of 50 mg/kg of NiCl2\&nbsp;by s.c. injection increased erythropoiesis at day 20 of gestation and decreased platelets counts. In addition, administration of 100 mg/kg of NiCl2\&nbsp;markedly reduced the maternal body weight and number of live fetuses and increased fetal loss, predominantly at the end of the experimental period. All dose levels of NiCl2\&nbsp;caused an alteration in the hepatic histoarchitecture. When 0.3-mg/kg Se was injected s.c. with 100-mg/kg NiCl2, the levels of plasma AST and ALT and the structure of the liver were restored. Administration of 20 mg/L/day of NiCl2\&nbsp;in the drinking water significantly reduced the maternal body weight at day five of gestation as well as erythropoiesis during the exposure period. The present study suggests that Se can counteract the nocuous effect of nickel on the liver; however this antioxidant did not prevent alterations in development and erythropoiesis. {\textcopyright} 2011 Wiley Periodicals, Inc. Environ Toxicol 2013.},
	author = {Adjroud, Ounassa}
}
@proceedings {67124,
	title = {Antagonistic Role of Selenium against Hepatotoxic Effects of Nicl2 in Preimplanted Wistar Albino Rats},
	journal = {Sixth International Conference on Environmental Mutagens in Human Populations},
	volume = {2012},
	year = {2012},
	month = {2012},
	pages = {88},
	publisher = {Hamad bin Khalifa University Press (HBKU Press)},
	isbn = {2226-9649},
	author = {Adjroud, Ounassa}
}
@proceedings {67596,
	title = {Effets protecteurs du s{\'e}l{\'e}nium contre l{\textquoteright}h{\'e}matotoxicit{\'e} induite par le dichromate de potassium chez les rats femelles et m{\^a}les albinos Wistar},
	journal = {Annales de toxicologie analytique},
	volume = {22},
	year = {2010},
	month = {2010},
	pages = {165-172},
	publisher = {Soci{\'e}t{\'e} fran{\c c}aise de toxicologie analytique},
	isbn = {0768-598X},
	author = {Adjroud, Ounassa}
}
@proceedings {67597,
	title = {Protective effects of selenium against potassium dichromate-induced hematotoxicity in female and male Wistar albino rats},
	journal = {Annales de Toxicologie Analytique},
	volume = {22},
	year = {2010},
	month = {2010},
	pages = {165-172},
	publisher = {EDP Sciences},
	isbn = {0768-598X},
	author = {Adjroud, Ounassa}
}
@article {61735,
	title = {Peripheral excitatory effects of two enkephalinase inhibitors, acetorphan and thiorphan, and an enkephalin analogue},
	journal = {Society for Reproduction and FertilitySociety for Reproduction and Fertility},
	volume = {104},
	year = {1995},
	month = {1995},
	pages = {181{\textendash}186},
	abstract = {The effects of two enkephalinase inhibitors, acetorphan and thiorphan, and the enkephalin analogue [d-Ala2\p=n-\Met5]-enkephalinamide (DAMEA), on spontaneous uterine contractions were studied at day 21 of pregnancy in rats following treatment in vivo or in vitro. Acetorphan (10 mg kg\m=-\1)and thiorphan (1 mg kg\m=-\1),immediately after their i.v. administration, increased the duration of spontaneous contractions 3.4- and 4.6-fold, respectively, but did not modify the maximum amplitude. Similarly, thiorphan (40 \g=m\moll\m=-\1) increased the duration of contractions when administered in vitro. Thiorphan was ineffective during the first 30 min when given into the cerebral ventricles (50 \g=m\gper rat). These results suggest that the enkephalinase inhibitors are acting via a peripheral opioid pathway; and this conclusion is supported by the observation that thiorphan potentiated the stimulatory effect of a submaximal dose of DAMEA administered in vitro. The excitatory effects of DAMEA and the enkephalinase inhibitors were blocked by naloxone. This antagonistic effect of naloxone on uterine motility in the periparturient rat uterus, induced by either acetorphan and thiorphan or DAMEA, seems to be regulated by peripheral opiate receptors. Naloxone (10 mg kg\m=-\1 s.c.) increased both the amplitude and duration of uterine motility in vivo; however, naloxone (26 \g=m\moll\m=-\1 and 52 \g=m\moll\m=-\1) produced a paradoxical dose-dependent biphasic effect in vitro.},
	author = {Adjroud, Ounassa}
}
@article {61709,
	title = {Identification d{\textquoteright}une r{\'e}activit{\'e} enk{\'e}phalinergique de l{\textquoteright}ut{\'e}rus chez la ratte pr{\'e}parturiente. Interaction des Enk{\'e}phalines avec quelques facteurs de r{\'e}gulation de la motricit{\'e} ut{\'e}rine},
	year = {1988},
	month = {1988},
	author = {Adjroud, Ounassa}
}
