@article {93545,
	title = {CHRONIC THIACLOPRID EXPOSURE IMPAIRS COGNITIVE FUNCTION AND TRIGGERS MITOCHONDRIAL APOPTOSIS PATHWAY IN RAT STRIATUM AND HIPPOCAMPUS: NEUROPREVENTIVE EFFECT OF BITTER APRICOT KERNELS EXTRACT (PRUNUS ARMENIACA L.)},
	journal = {The Journal of Microbiology, Biotechnology and Food Sciences},
	year = {2022},
	abstract = {Thiacloprid (THI) is a nicotinic receptor agonist widely used as pesticide in Algeria, however it is susceptible to accumulate in various fruits and vegetables and pouringdownstream into food platesandcontributesto the development of neurodegenerative diseases. Conversely, several natural compounds are provided with cytoprotective potential and, therefore, are able to act against the harmful effects of toxicants such as pesticides. This study focused on striatum (str) and hippocampus (hipp) mitochondrial toxicityassessment, evaluation of behavioral function and intrinsic apoptosis pathway in rats exposed to THI at low-dose (0.020 mg/kg) for 3 months. In addition, this study examined neuroprotective potential of bitter apricot kernel extract when administered concomitantly with THI at the dose of 50 mg/kg. In current study, assessment of mitochondrial permeability transition pore (mPTP) and swelling, evaluation of mitochondrial redox status, cholinergic function (Ach E) and apoptosis markers (Caspase 9 and 3, Bax and Bcl2, Cytochrome c and cytosolic calcium) were performedin both brainareas, besides behavioral and histopathological examination. The results showed an increase of lipid peroxidation in both of str and hippwith a values of 1,14 {\textpm} 0,04nmol/mg of proteins(pr)and 1,58 {\textpm} 0,09nmol/mg pr.respectively and a significant decrease in GSH(0,09 {\textpm} 0,01mmol/mg pr.in hipp and 0,08{\textpm}0,01mmol/mg pr. in str), the results also showed a change in the activity of antioxidants enzymes SOD (16,37{\textpm}1,09UI/mg pr.in hipp14,54{\textpm}1,46UI/mg pr.in str) , CAT (0,010{\textpm}0,01UI/mg pr.in hipp and 0,005{\textpm}0,004UI/mg pr.in str), GPx (0,01{\textpm} 0,001nmol/mg pr.in both hippand str) and GST (23,73{\textpm}1,68UI/mg pr.in hipp and 17,56{\textpm} 1,04UI/mg pr.in str), as well as an abrupt increase in mPTP opening with a value of (0,057{\textpm}0,005 in str and 0,054{\textpm}0,005 in hipp) , which leaded to mitochondrial swelling where the level o mitochondrial swelling was (0,016{\textpm}0,002 in str and 0,106{\textpm}0,003 in hipp), the swelling was associated also with a high releasing of Cyt-c with a values of (4,48 {\textpm} 1,26μg/mlin str and 5,32 {\textpm} 1,08 μg/mlin hipp ) and Ca++( 2,26{\textpm}0,06mmol/lin str and 2,32{\textpm}0,07mmol/lin hipp) into the cytosol, the results also showed a significant decreasing of Bcl2 (16,4 {\textpm} 1,86ng/mg prin str and 14,8{\textpm} 0,82ng/mg prin hipp), in the other hand the rates of caspase-9 were (278{\textpm}14mAbs/mg pr.)in str and 212 {\textpm}24mAbs/mg pr.in hipp), caspase3 (184{\textpm} 16mAbs/mg pr.)in str and 250 {\textpm}14mAbs/mg pr.in hipp), and BAX (0,926ng/mg prin str and 1,189ng/mg prin hipp) were increased. The results of this study revealed also a decrease of memorization processes and learning abilities, at the same time a decrease in Ach E activity (14,02{\textpm} 0,78 nmol/min/mg pr.in str and 22,35{\textpm} 1,77 nmol/min/mg pr.in hipp) was recorded. Inversely, bitter apricot kernels extract showed higher cytoprotective potential against THI neurotoxicity, since mitochondrial redox homeostasis and membrane integrity were recovered, cognitive impairment and brain tissue damage were also prevented. In conclusion, THI induced mitochondrial disorders, triggered apoptosis signaling pathway and impaired cognitive functions whichwere prevented by bitter apricot kernels extract when associated with this pesticide.},
	url = {https://office2.jmbfs.org/index.php/JMBFS/article/view/9089/3315},
	author = {Djellal, Dounia and Haddad, Souhila and Gasmi, Salim and Chouit, Zeyneb and Kebieche, Mohamed and Hachemi, Messaoud and HANFER, Mourad and Nouicer Ferhat and Bennoune, Omar and Fetoui, Hamadi and Soulimani, Rachid}
}
@article {62479,
	title = {Chemical constituents, in vitro anti-inflammatory, antioxidant and hemostatic activities of then-butanol extract ofHyacinthoides lingulata (Poir.) Rothm},
	journal = {Natural Product Research},
	year = {2022},
	month = {2022},
	abstract = {
	The phytochemical profile obtained from LC-ESI-MS/MS analysis of then-butanol extract (BEHL) from the North African endemic plantHyacinthoides lingulata\&nbsp;(Poir.) Rothm. brought about the identification of ten glycosylated derivatives of apigenin and luteolin flavones. For the same plant extract,in\&nbsp;vitro\&nbsp;anti-inflammatory (hypotonic induced hemolysis and heat induced haemolysis assay) and antioxidant (DPPH andβ-Carotene) activities were evaluated observing high inflammatory inhibition by protecting membrane stability of erythrocyte in both heat (84.70 {\textpm} 0.24\%) and hypotonic induced hemolysis (79.45 {\textpm} 0.12\%). A remarkable hemostatic effect was also established by measuring the coagulation time (15.95\&nbsp;{\textpm}\&nbsp;1.05 s at a dose of 1 mg/mL) of decalcified plasma related to its phytochemical content. It is the first report on combined chemical components and biological evaluation of this specific plant.

},
	isbn = {1478-6419},
	url = {https://doi.org/10.1080/14786419.2021.1937153},
	author = {HANFER, Mourad and Benramdane, Zeyneb and Cheriet, Thamere and Sarri, Djamel and Menad, Ahmed and Mancini, Ines and Seghiri, Ramdane and Ameddah, Souad}
}
@article {62672,
	title = {Anti-inflammatory and hemostatic effects of Linaria reflexa Desf},
	journal = {Natural Product Research},
	volume = {35},
	number = {16},
	year = {2021},
	month = {2021},
	pages = {2778-2783},
	abstract = {
	The work presented here was aimed to investigate the\&nbsp;in vivo\&nbsp;anti-inflammatory and\&nbsp;in vitro\&nbsp;hemostatic activities of\&nbsp;Linaria reflexa\&nbsp;extract and to establish the relationship between its bioactivity and chemical composition. Twenty-three secondary metabolites were identified, most of them are good anti-inflammatory agents, in line with data by carrageenin-induced rat paw edema assays of the\&nbsp;n-butanol extract showing high anti-inflammatory inhibition (63.90\%) of edema swelling in the rat paw at the dose 200 mg/kg after 4 h. Furthermore, both extent of inflammatory response and tissue injury were prevented keeping the levels of rate myeloperoxidase (60.16\%) and of malondialdehyde, which is the final product of lipid peroxidation generated by free radicals (58.58\%). The same extract showed also a remarkable hemostatic effect established by measuring the coagulation time of decalcified plasma (45 s), related to its flavonoid glycosides content.

},
	isbn = {1478-6419},
	url = {https://pubmed.ncbi.nlm.nih.gov/31507213/},
	author = {Cheriet, Thamere and HANFER, Mourad and Mancini, Ines and Benelhadj, Samiha and Laouas, Nour Essabah and Ameddah, Souad and Menad, Ahmed and Seghiri, Ramdane}
}
@article {62619,
	title = {Chemical constituents, in vitro anti-inflammatory, antioxidant and hemostatic activities of the n-butanol extract of Hyacinthoides lingulata (Poir.) Rothm},
	journal = {Natural Product Research},
	volume = {36},
	number = {12},
	year = {2021},
	month = {2021},
	pages = {3124-3128},
	abstract = {
	The phytochemical profile obtained from LC-ESI-MS/MS analysis of the\&nbsp;n-butanol extract (BEHL) from the North African endemic plant\&nbsp;Hyacinthoides lingulata\&nbsp;(Poir.) Rothm. brought about the identification of ten glycosylated derivatives of apigenin and luteolin flavones. For the same plant extract,\&nbsp;in vitro\&nbsp;anti-inflammatory (hypotonic induced hemolysis and heat induced haemolysis assay) and antioxidant (DPPH and\&nbsp;β-Carotene) activities were evaluated observing high inflammatory inhibition by protecting membrane stability of erythrocyte in both heat (84.70 {\textpm} 0.24\%) and hypotonic induced hemolysis (79.45 {\textpm} 0.12\%). A remarkable hemostatic effect was also established by measuring the coagulation time (15.95 {\textpm} 1.05 s at a dose of 1 mg/mL) of decalcified plasma related to its phytochemical content. It is the first report on combined chemical components and biological evaluation of this specific plant.

},
	isbn = {1478-6419},
	url = {https://pubmed.ncbi.nlm.nih.gov/34121529/},
	author = {HANFER, Mourad and Benramdane, Zeyneb and Cheriet, Thamere and Sarri, Djamel and Menad, Ahmed and Mancini, Ines and Seghiri, Ramdane and Ameddah, Souad}
}
@article {62664,
	title = {Potentiation of the apoptotic signaling pathway in both the striatum and hippocampus and neurobehavioral impairment in rats exposed chronically to a low- dose of cadmium},
	journal = {Environmental Science and Pollution ResearchEnvironmental Science and Pollution Research},
	volume = {28},
	year = {2021},
	month = {2021},
	pages = {3307-3317},
	isbn = {1614-7499},
	author = {Chouit, Zeyneb and Djellal, Dounia and Haddad, Souhila and HANFER, Mourad and Hachemi, Messaoud and Lakroun, Zhoura and Chafaa, Smail and Fetoui, Hamadi and Kebieche, Mohamed and Soulimani, Rachid}
}
@article {62963,
	title = {Chemical composition, in vitro antiparasitic, antimicrobial and antioxidant activities of Frankenia thymifolia Desf.},
	journal = {Natural Product ResearchNatural Product Research},
	volume = {34},
	year = {2020},
	month = {2020},
	pages = {3363-3368},
	isbn = {1478-6419},
	author = {Mennai, Imad and HANFER, Mourad and Esseid, Chahrazed and Benayache, Samir and Ameddah, Souad and Menad, Ahmed and Benayache, Fadila}
}
@article {63411,
	title = {HPLC profile and in vitro antioxidant properties of the n-butanol extract of Linaria tingitana Boiss. and Reut},
	journal = {J Chem Pharm ResJ Chem Pharm Res},
	volume = {11},
	year = {2019},
	month = {2019},
	pages = {50-58},
	author = {HANFER, Mourad and Cheriet, Thamere and Menad, Ahmed and Seghiri, Ramdane and Ameddah, Souad}
}
@article {61570,
	title = {Retentissement de la vitamine B12 sur l\&rsquo;an{\'e}mie macrocytaire (an{\'e}mie m{\'e}galoblastique)},
	year = {2019},
	author = {HANFER, Mourad and MENIA, Hassiba and DJEBABRA, Hedda and DRIS, Ghania}
}
@article {64920,
	title = {Modulation of liver glutathione-dependent enzymes and steatosis by Linaria tingitana in sodium valproate-treated rats},
	journal = {Journal of Herbs, Spices \& Medicinal PlantsJournal of Herbs, Spices \& Medicinal Plants},
	volume = {24},
	year = {2018},
	month = {2018},
	pages = {173-184},
	isbn = {1049-6475},
	author = {HANFER, Mourad and Cheriet, Thamere and Menad, Ahmed and Seghiri, Ramdane and Benayache, Samir and Benayache, Fadila and Ameddah, Souad}
}
@article {64448,
	title = {Glycosyl flavonoid profile, in vivo antidiabetic and in vitro antioxidant properties of Linaria reflexa Desf.},
	journal = {Natural product researchNatural Product Research},
	volume = {31},
	year = {2017},
	month = {2017},
	pages = {2042-2048},
	isbn = {1478-6419},
	author = {Cheriet, Thamere and HANFER, Mourad and Boudjelal, Amel and Baali, Nadir and Mancini, Ines and Seghiri, Ramdane and Ameddah, Souad and Menad, Ahmed and Benayache, Fadila and Benayache, Samir}
}
@article {64358,
	title = {Iridoids and anti-inflammatory properties of n-butanol extract of Linaria tingitana Boiss. \& Reut.},
	journal = {Natural Product ResearchNatural Product Research},
	volume = {31},
	year = {2017},
	month = {2017},
	pages = {2008-2015},
	isbn = {1478-6419},
	author = {HANFER, Mourad and Cheriet, Thamere and Ameddah, Souad and Mancini, Ines and Seghiri, Ramdane and Menad, Ahmed and Benayache, Samir and Benayache, Fadila}
}
@article {64359,
	title = {L{\textquoteright}effet protecteur de la plante Linaria tingitana (Scrophulariaceae) sur le dysfonctionnement mito chondrial et lysosomal h{\'e}pato cytaire induit par l{\textquoteright}acide valpro{\"\i}que chez le rat},
	year = {2017},
	month = {2017},
	author = {HANFER, Mourad and Ameddah, Souad and Morin, Didier}
}
@article {61619,
	title = {R{\^o}le du stress oxydant dans l\&rsquo;apparition des l{\'e}sions muqueuses gastriques},
	year = {2017},
	author = {Mezdour, Hichem and HANFER, Mourad and Menad, Ahmed and Ameddah, Souad}
}
