<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cheriet, Thamere</style></author><author><style face="normal" font="default" size="100%">HANFER, Mourad</style></author><author><style face="normal" font="default" size="100%">Mancini, Ines</style></author><author><style face="normal" font="default" size="100%">Benelhadj, Samiha</style></author><author><style face="normal" font="default" size="100%">Laouas, Nour Essabah</style></author><author><style face="normal" font="default" size="100%">Ameddah, Souad</style></author><author><style face="normal" font="default" size="100%">Menad, Ahmed</style></author><author><style face="normal" font="default" size="100%">Seghiri, Ramdane</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory and hemostatic effects of Linaria reflexa Desf</style></title><secondary-title><style face="normal" font="default" size="100%">Natural Product Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2021</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://pubmed.ncbi.nlm.nih.gov/31507213/</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">16</style></number><volume><style face="normal" font="default" size="100%">35</style></volume><pages><style face="normal" font="default" size="100%">2778-2783</style></pages><isbn><style face="normal" font="default" size="100%">1478-6419</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;
	The work presented here was aimed to investigate the&amp;nbsp;&lt;i&gt;in vivo&lt;/i&gt;&amp;nbsp;anti-inflammatory and&amp;nbsp;&lt;i&gt;in vitro&lt;/i&gt;&amp;nbsp;hemostatic activities of&amp;nbsp;&lt;i&gt;Linaria reflexa&lt;/i&gt;&amp;nbsp;extract and to establish the relationship between its bioactivity and chemical composition. Twenty-three secondary metabolites were identified, most of them are good anti-inflammatory agents, in line with data by carrageenin-induced rat paw edema assays of the&amp;nbsp;&lt;i&gt;n&lt;/i&gt;-butanol extract showing high anti-inflammatory inhibition (63.90%) of edema swelling in the rat paw at the dose 200 mg/kg after 4 h. Furthermore, both extent of inflammatory response and tissue injury were prevented keeping the levels of rate myeloperoxidase (60.16%) and of malondialdehyde, which is the final product of lipid peroxidation generated by free radicals (58.58%). The same extract showed also a remarkable hemostatic effect established by measuring the coagulation time of decalcified plasma (45 s), related to its flavonoid glycosides content.
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