<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bensaad ,Mohamed-Sabri</style></author><author><style face="normal" font="default" size="100%">Dassamiour, Saliha</style></author><author><style face="normal" font="default" size="100%">Hambaba, Leila</style></author><author><style face="normal" font="default" size="100%">Kahoul, Mohamed-Amine</style></author><author><style face="normal" font="default" size="100%">Benhoula, Mohammed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evidence of anti-inflammatory and anti-ulcer properties of aerial parts of Centaurea tougourensis Boiss. and Reut</style></title><secondary-title><style face="normal" font="default" size="100%">Tropical Journal of Pharmaceutical Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2021</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.ajol.info/index.php/tjpr/article/view/221659</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">8</style></number><volume><style face="normal" font="default" size="100%">20</style></volume><isbn><style face="normal" font="default" size="100%">1596-5996</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;
	&lt;strong&gt;Purpose:&lt;/strong&gt;&amp;nbsp;To determine the anti-inflammatory and anti-ulcer properties of the aerial parts of&amp;nbsp;&lt;em&gt;Centaurea tougourensis&lt;/em&gt;&amp;nbsp;Boiss. &amp;amp; Reut.
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	&lt;strong&gt;Methods:&lt;/strong&gt;&amp;nbsp;The effects of n-butanol (n-BuOH) extract of the aerial part of&amp;nbsp;&lt;em&gt;Centaurea tougourensis&lt;/em&gt;&amp;nbsp;on carrageenan-induced paw edema and ethanol-induced gastric mucosal damage were determined at 2 doses (200 and 400 mg/kg, po) in a mouse model. For each test, the animals were randomly divided into negative and positive control groups, as well as extract-treated groups. The mice were observed for any sign of inflammation for a period of 24h.
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	&lt;strong&gt;Results:&lt;/strong&gt;&amp;nbsp;Reduction of paw edema by&amp;nbsp;&lt;em&gt;C. tougourensis&lt;/em&gt;&amp;nbsp;extract was highly significant (p &amp;lt; 0.001) at a dose of 400 mg/kg 24 h after carrageenan injection, with 55.26 % inhibition, followed very closely by 53.15 % inhibition at the dose of 200 mg/kg; indomethacin group showed an inhibition of 60 %. Histological examination supported the inhibition results. A significant reduction in inflammation by the extract at a dose of 400 mg/kg was also observed. No sign of ulcer was observed with&amp;nbsp;&lt;em&gt;C. tougourensis&amp;nbsp;&lt;/em&gt;at the two doses (200 and 400 mg/kg). The total polyphenol content of the n-BuOH extract was 85.44 цg gallic acid equivalent/mg of extract. Tannins were the most abundant fraction (51.87 цg tannic acid equivalent/mg of extract), followed by flavonoids (25.55 цg quercetin equivalent/mg of extract).
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	&lt;strong&gt;Conclusion:&lt;/strong&gt;&amp;nbsp;The results indicate that&amp;nbsp;&lt;em&gt;C. tougourensis&lt;/em&gt;&amp;nbsp;may have potential beneficial effects in the treatment of diseases associated with inflammation and pain, besides its protective effect on the gastrointestinal tract.
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