<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rezgui, A.</style></author><author><style face="normal" font="default" size="100%">Mitaine-Offer, A.-C.</style></author><author><style face="normal" font="default" size="100%">Miyamoto, T.</style></author><author><style face="normal" font="default" size="100%">Tanaka, C.</style></author><author><style face="normal" font="default" size="100%">Delemasure, S.</style></author><author><style face="normal" font="default" size="100%">Dutartre, P.</style></author><author><style face="normal" font="default" size="100%">Lacaille-Dubois, M.-A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">New triterpenoid saponins with cytotoxic and anti-inflammatory properties from Weigela stelzneri</style></title><secondary-title><style face="normal" font="default" size="100%">Planta Medica 81(16) DOI: 10.1055/s-0035-1565571Planta Medica 81(16) DOI: 10.1055/s-0035-1565571</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">81</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Saponins are bioactive compounds occurring in many plant species having a wide range of biological activities such as immunoadjuvant, cytotoxic, analgesic, antimicrobial and anti-inflammatory activities, just to mention a few. The aim of our researches concerns the isolation, structural elucidation and biological investigation of saponins from various plant species [1]. In this context, the study of the roots and leaves of&amp;nbsp;Weigela stelzneri(Caprifoliaceae) led to isolation of four new and two known oleanane-type saponins mainly by medium pressure- and vacuum-liquid chromatography on silica gel (normal and reversed-phase RP-18) [1]. The new compounds were elucidated by a combination of spectroscopic techniques including 1D-, 2D-NMR, and mass spectrometry as glycosides of oleanolic acid, three of them being monodesmosides at C-3 with a branched oligosaccharidic chain made of six sugar units, whereas the known ones were hederagenin derivatives. The six compounds were evaluated for their cytotoxicity against a human cancer cell line (colorectal SW480) and a mouse cancer cell line (mammary EMT6), and for their anti-inflammatory activity. The results show that two new compounds differing only by the first sugar unit of the hexasaccharidic chain at C-3 (arabinopyranosyl instead of xylopyranosyl) exhibited the strongest cytotoxicity on both cell lines (IC50&amp;nbsp;5.41 µM and 1.54 µM, respectively), which was better than those of the positive controls etoposide and methotrexate. Furthermore, they revealed a significant modulatory effect of the IL-1β production on human lymphocytes stimulated with endotoxins, showing therefore a strong anti-inflammatory potential.</style></abstract></record></records></xml>