Aiming to provide a generalized method for assessing the performance of safety instrumented systems with a flexible and accurate consideration of the common cause failures’ contribution. This paper is devoted to the development of a direct way to generate the transition rate matrix associated with the continuous-time Markov model of any typical KooN architecture using any parametric model. Such a choice is considered after a detailed comparison of the ability of several dependability methods (e.g., fault trees, reliability block diagrams, Markov models, Bayesian networks, etc) to provide simple representations and genuine results in this context. To validate the developed method, the unavailability and the unconditional failure intensity of a wide range of configurations are quantified using the Binomial Failure Rate model and compared to those of the complete fault tree implementation.