Digital twins have transformed the industrial world by changing the development phase of a product or the use of equipment. With the digital twin, the object’s evolution data allows us to anticipate and optimize its performance. Healthcare is in the midst of a digital transition towards personalized, predictive, preventive, and participatory medicine. The digital twin is one of the key tools of this change. In this work, DT is proposed for the diagnosis of breast cancer based on breast skin temperature. Research has focused on thermography as a non-invasive scanning solution for breast cancer diagnosis. However, body temperature is influenced by many factors, such as breast anatomy, physiological functions, blood pressure, etc. The proposed DT updates the bio-heat model’s temperature using the data collected by temperature sensors and complementary data from smart devices. Consequently, the proposed DT is personalized using the collected data to reflect the person’s behavior with whom it is connected.

A recent study from GLOBOCAN disclosed that during 2018 two million women worldwide had been diagnosed with breast cancer. Currently, mammography, magnetic resonance imaging, ultrasound, and biopsies are the main screening techniques, which require either, expensive devices or personal qualified; but some countries still lack access due to economic, social, or cultural issues. As an alternative diagnosis methodology for breast cancer, this study presents a computer-aided diagnosis system based on convolutional neural networks (CNN) using thermal images. We demonstrate that CNNs are faster, reliable and robust when compared with different techniques. We study the influence of data pre-processing, data augmentation and database size on several CAD models. Among the 57 patients database, our CNN models obtained a higher accuracy (92%) and F1-score (92%) that outperforms several state-of-the-art architectures such as ResNet50, SeResNet50, and Inception. This study exhibits that a CAD system that implements data-augmentation techniques reach identical performance metrics in comparison with a system that uses a bigger database (up to 33%) but without data-augmentation. Finally, this study proposes a computer-aided system for breast cancer diagnosis but also, it stands as baseline research on the influence of data-augmentation and database size for breast cancer diagnosis from thermal images with CNNs