Introduction: Traditional medicine has an important place in human history and this since antiquity. Indeed, during Egyptian and Chinese civilization era, many detailed manuscripts, describing the therapeutic effect of plants, were found which suggest that folk medicine is the basis of the actual medicine. Objective: To investigate the phytochemical and pharmacological properties of the n-butanol (n-BuOH) and ethyl acetate (EA) extracts of the aerial part of Centaurea tougourensis. Methods: The phytochemical evaluation was done based on HPLC-DAD approach. The antioxidant activity was determined by DPPH and cupric ion reducing antioxidant capacity (CUPRAC), while the hemostatic effect was performed using plasma recalcification time (PRT) method. The antidiabetic capacity was investigated by alpha-amylase inhibition assay and the photoprotective test was evaluated by the measurement of sun protection factor (SPF). Results: 13 phenolic compounds were identified in both extracts of C. tougourensis. These extracts showed antioxidant, haemostatic, antidiabetic and photoprotective properties with a dose-dependent manner. Amounts of n-BuOH activities were found higher, with a respective IC50 value of 0.72±0.07 μg/ml in DPPH assay, an A0.50 value lower than 3.125 μg/ml in CUPRAC assay besides a shortening rate percentage of coagulation (86.71%) in haemostatic assay, a moderate inhibition effect on alpha amylase activity with an IC50 value of (711.5±0.03 μg/ml) and a maximum sun protection factor of (56.035). These results were mostly found highly significant (p<0.001) when compared to respective standards. Conclusion: This study demonstrated some pharmacological effects of C. tougourensis which suggests that our plant could be a good candidate to treat some illnesses related to oxidative stress, bleeding or skin cancer.

Introduction: Traditional medicine has an important place in human history and this since antiquity. Indeed, during Egyptian and Chinese civilization era, many detailed manuscripts, describing the therapeutic effect of plants, were found which suggest that folk medicine is the basis of the actual medicine. Objective: To investigate the phytochemical and pharmacological properties of the n-butanol (n-BuOH) and ethyl acetate (EA) extracts of the aerial part of Centaurea tougourensis. Methods: The phytochemical evaluation was done based on HPLC-DAD approach. The antioxidant activity was determined by DPPH and cupric ion reducing antioxidant capacity (CUPRAC), while the hemostatic effect was performed using plasma recalcification time (PRT) method. The antidiabetic capacity was investigated by alpha-amylase inhibition assay and the photoprotective test was evaluated by the measurement of sun protection factor (SPF). Results: 13 phenolic compounds were identified in both extracts of C. tougourensis. These extracts showed antioxidant, haemostatic, antidiabetic and photoprotective properties with a dose-dependent manner. Amounts of n-BuOH activities were found higher, with a respective IC50 value of 0.72±0.07 μg/ml in DPPH assay, an A0.50 value lower than 3.125 μg/ml in CUPRAC assay besides a shortening rate percentage of coagulation (86.71%) in haemostatic assay, a moderate inhibition effect on alpha amylase activity with an IC50 value of (711.5±0.03 μg/ml) and a maximum sun protection factor of (56.035). These results were mostly found highly significant (p<0.001) when compared to respective standards. Conclusion: This study demonstrated some pharmacological effects of C. tougourensis which suggests that our plant could be a good candidate to treat some illnesses related to oxidative stress, bleeding or skin cancer.

In this paper, we address the integration of a two-level supply chain with multiple items. This two-level production-distribution system features a capacitated production facility supplying several retailers located in the same region. If production does occur, this process incurs a fixed setup cost and unit production costs. Besides, deliveries are made from the plant to the retailers by a limited number of capacitated vehicles, routing costs incurred. This work aims to implement a minimization solution that reduces the total costs in both the production facility and retailers. The methodology adopted based on a hybrid heuristic, greedy and genetic algorithm uses strong formulation to provide a suitable solution of a guaranteed quality that is as good or better than those provided by the MIP optimizer. The results demonstrate that the proposed heuristics are effective and performs impressively in terms of computational efficiency and solution quality.

In this paper, we address the integration of a two-level supply chain with multiple items. This two-level production-distribution system features a capacitated production facility supplying several retailers located in the same region. If production does occur, this process incurs a fixed setup cost and unit production costs. Besides, deliveries are made from the plant to the retailers by a limited number of capacitated vehicles, routing costs incurred. This work aims to implement a minimization solution that reduces the total costs in both the production facility and retailers. The methodology adopted based on a hybrid heuristic, greedy and genetic algorithm uses strong formulation to provide a suitable solution of a guaranteed quality that is as good or better than those provided by the MIP optimizer. The results demonstrate that the proposed heuristics are effective and performs impressively in terms of computational efficiency and solution quality.

In recent years, some efforts have been devoted to nonlinear dynamics of fractional discrete-time systems. A number of papers have so far discussed results related to the presence of chaos in fractional maps. However, less results have been published to date regarding the presence of hyperchaos in fractional discrete-time systems. This paper aims to bridge the gap by introducing a new three-dimensional fractional map that shows, for the first time, complex hyperchaotic behaviors. A detailed analysis of the map dynamics is conducted via computation of Lyapunov exponents, bifurcation diagrams, phase portraits, approximated entropy and Co complexity. Simulation results confirm the effectiveness of the approach illustrated herein.

In recent years, some efforts have been devoted to nonlinear dynamics of fractional discrete-time systems. A number of papers have so far discussed results related to the presence of chaos in fractional maps. However, less results have been published to date regarding the presence of hyperchaos in fractional discrete-time systems. This paper aims to bridge the gap by introducing a new three-dimensional fractional map that shows, for the first time, complex hyperchaotic behaviors. A detailed analysis of the map dynamics is conducted via computation of Lyapunov exponents, bifurcation diagrams, phase portraits, approximated entropy and Co complexity. Simulation results confirm the effectiveness of the approach illustrated herein.

In recent years, some efforts have been devoted to nonlinear dynamics of fractional discrete-time systems. A number of papers have so far discussed results related to the presence of chaos in fractional maps. However, less results have been published to date regarding the presence of hyperchaos in fractional discrete-time systems. This paper aims to bridge the gap by introducing a new three-dimensional fractional map that shows, for the first time, complex hyperchaotic behaviors. A detailed analysis of the map dynamics is conducted via computation of Lyapunov exponents, bifurcation diagrams, phase portraits, approximated entropy and Co complexity. Simulation results confirm the effectiveness of the approach illustrated herein.

In recent years, some efforts have been devoted to nonlinear dynamics of fractional discrete-time systems. A number of papers have so far discussed results related to the presence of chaos in fractional maps. However, less results have been published to date regarding the presence of hyperchaos in fractional discrete-time systems. This paper aims to bridge the gap by introducing a new three-dimensional fractional map that shows, for the first time, complex hyperchaotic behaviors. A detailed analysis of the map dynamics is conducted via computation of Lyapunov exponents, bifurcation diagrams, phase portraits, approximated entropy and Co complexity. Simulation results confirm the effectiveness of the approach illustrated herein.

In recent years, some efforts have been devoted to nonlinear dynamics of fractional discrete-time systems. A number of papers have so far discussed results related to the presence of chaos in fractional maps. However, less results have been published to date regarding the presence of hyperchaos in fractional discrete-time systems. This paper aims to bridge the gap by introducing a new three-dimensional fractional map that shows, for the first time, complex hyperchaotic behaviors. A detailed analysis of the map dynamics is conducted via computation of Lyapunov exponents, bifurcation diagrams, phase portraits, approximated entropy and Co complexity. Simulation results confirm the effectiveness of the approach illustrated herein.

In recent years, some efforts have been devoted to nonlinear dynamics of fractional discrete-time systems. A number of papers have so far discussed results related to the presence of chaos in fractional maps. However, less results have been published to date regarding the presence of hyperchaos in fractional discrete-time systems. This paper aims to bridge the gap by introducing a new three-dimensional fractional map that shows, for the first time, complex hyperchaotic behaviors. A detailed analysis of the map dynamics is conducted via computation of Lyapunov exponents, bifurcation diagrams, phase portraits, approximated entropy and Co complexity. Simulation results confirm the effectiveness of the approach illustrated herein.

In recent years, some efforts have been devoted to nonlinear dynamics of fractional discrete-time systems. A number of papers have so far discussed results related to the presence of chaos in fractional maps. However, less results have been published to date regarding the presence of hyperchaos in fractional discrete-time systems. This paper aims to bridge the gap by introducing a new three-dimensional fractional map that shows, for the first time, complex hyperchaotic behaviors. A detailed analysis of the map dynamics is conducted via computation of Lyapunov exponents, bifurcation diagrams, phase portraits, approximated entropy and Co complexity. Simulation results confirm the effectiveness of the approach illustrated herein.

Most of the papers published so far on fractional discrete systems are related to theoretical results on their chaotic behaviors or to applications based on the mathematical modeling of the chaotic phenomena. No paper has been published to date regarding the hardware implementation of hyperchaotic fractional maps. This manuscript makes a contribution to the topic by presenting the first example of hardware implementation of hyperchaotic fractional maps. In particular, by exploiting the Grunwald–Letnikov difference operator, the paper introduces a new version of the fractional Grassi–Miller map. The system dynamics are analyzed via bifurcation diagrams and Lyapunov exponents, showing that the conceived map is hyperchaotic when the fractional order � belongs to the interval [0.966,1]. Finally, a hardware implementation of the fractional map is illustrated, with the aim to concretely highlight the presence of hyperchaos in physical systems described by fractional difference equations. Arduino, an open-source platform, has been used to illustrate the simplicity as well as the feasibility of the implementation.

Most of the papers published so far on fractional discrete systems are related to theoretical results on their chaotic behaviors or to applications based on the mathematical modeling of the chaotic phenomena. No paper has been published to date regarding the hardware implementation of hyperchaotic fractional maps. This manuscript makes a contribution to the topic by presenting the first example of hardware implementation of hyperchaotic fractional maps. In particular, by exploiting the Grunwald–Letnikov difference operator, the paper introduces a new version of the fractional Grassi–Miller map. The system dynamics are analyzed via bifurcation diagrams and Lyapunov exponents, showing that the conceived map is hyperchaotic when the fractional order � belongs to the interval [0.966,1]. Finally, a hardware implementation of the fractional map is illustrated, with the aim to concretely highlight the presence of hyperchaos in physical systems described by fractional difference equations. Arduino, an open-source platform, has been used to illustrate the simplicity as well as the feasibility of the implementation.

Most of the papers published so far on fractional discrete systems are related to theoretical results on their chaotic behaviors or to applications based on the mathematical modeling of the chaotic phenomena. No paper has been published to date regarding the hardware implementation of hyperchaotic fractional maps. This manuscript makes a contribution to the topic by presenting the first example of hardware implementation of hyperchaotic fractional maps. In particular, by exploiting the Grunwald–Letnikov difference operator, the paper introduces a new version of the fractional Grassi–Miller map. The system dynamics are analyzed via bifurcation diagrams and Lyapunov exponents, showing that the conceived map is hyperchaotic when the fractional order � belongs to the interval [0.966,1]. Finally, a hardware implementation of the fractional map is illustrated, with the aim to concretely highlight the presence of hyperchaos in physical systems described by fractional difference equations. Arduino, an open-source platform, has been used to illustrate the simplicity as well as the feasibility of the implementation.

Most of the papers published so far on fractional discrete systems are related to theoretical results on their chaotic behaviors or to applications based on the mathematical modeling of the chaotic phenomena. No paper has been published to date regarding the hardware implementation of hyperchaotic fractional maps. This manuscript makes a contribution to the topic by presenting the first example of hardware implementation of hyperchaotic fractional maps. In particular, by exploiting the Grunwald–Letnikov difference operator, the paper introduces a new version of the fractional Grassi–Miller map. The system dynamics are analyzed via bifurcation diagrams and Lyapunov exponents, showing that the conceived map is hyperchaotic when the fractional order � belongs to the interval [0.966,1]. Finally, a hardware implementation of the fractional map is illustrated, with the aim to concretely highlight the presence of hyperchaos in physical systems described by fractional difference equations. Arduino, an open-source platform, has been used to illustrate the simplicity as well as the feasibility of the implementation.

Most of the papers published so far on fractional discrete systems are related to theoretical results on their chaotic behaviors or to applications based on the mathematical modeling of the chaotic phenomena. No paper has been published to date regarding the hardware implementation of hyperchaotic fractional maps. This manuscript makes a contribution to the topic by presenting the first example of hardware implementation of hyperchaotic fractional maps. In particular, by exploiting the Grunwald–Letnikov difference operator, the paper introduces a new version of the fractional Grassi–Miller map. The system dynamics are analyzed via bifurcation diagrams and Lyapunov exponents, showing that the conceived map is hyperchaotic when the fractional order � belongs to the interval [0.966,1]. Finally, a hardware implementation of the fractional map is illustrated, with the aim to concretely highlight the presence of hyperchaos in physical systems described by fractional difference equations. Arduino, an open-source platform, has been used to illustrate the simplicity as well as the feasibility of the implementation.

Most of the papers published so far on fractional discrete systems are related to theoretical results on their chaotic behaviors or to applications based on the mathematical modeling of the chaotic phenomena. No paper has been published to date regarding the hardware implementation of hyperchaotic fractional maps. This manuscript makes a contribution to the topic by presenting the first example of hardware implementation of hyperchaotic fractional maps. In particular, by exploiting the Grunwald–Letnikov difference operator, the paper introduces a new version of the fractional Grassi–Miller map. The system dynamics are analyzed via bifurcation diagrams and Lyapunov exponents, showing that the conceived map is hyperchaotic when the fractional order � belongs to the interval [0.966,1]. Finally, a hardware implementation of the fractional map is illustrated, with the aim to concretely highlight the presence of hyperchaos in physical systems described by fractional difference equations. Arduino, an open-source platform, has been used to illustrate the simplicity as well as the feasibility of the implementation.

Tunnel FETisone of thealternativedevicefor low power electronics having steep subthreshold swing and lower leakage current than conventional MOSFET. In this research work, we have implemented the idea of high -k gate dielectric ondouble gate Tunnel FET, DG-TFETfor improvement of device features.An extensive investigation for the analog/RF and linearity feature of DG-TFET has been donehere for low power circuit and system development.Several essential analog/RF and linearity parameters like transconductance(gm), transconductance generation factor (gm/IDS) its high-order derivatives (gm2, gm3), cut-off frequency (fT), gain band width product (GBW), transconductance generation factor (gm/IDS) has been investigated for low power RF applications.The VIP2, VIP3, IMD3, IIP3, distortion characteristics (HD2, HD3), 1- dB the compression point, delay and power delay product performancehave also been throughly studied.It has been observed that the device features discussed for circuitry applications are found to be sensitiveto of gate materials, design configuration and input signals.

Tunnel FETisone of thealternativedevicefor low power electronics having steep subthreshold swing and lower leakage current than conventional MOSFET. In this research work, we have implemented the idea of high -k gate dielectric ondouble gate Tunnel FET, DG-TFETfor improvement of device features.An extensive investigation for the analog/RF and linearity feature of DG-TFET has been donehere for low power circuit and system development.Several essential analog/RF and linearity parameters like transconductance(gm), transconductance generation factor (gm/IDS) its high-order derivatives (gm2, gm3), cut-off frequency (fT), gain band width product (GBW), transconductance generation factor (gm/IDS) has been investigated for low power RF applications.The VIP2, VIP3, IMD3, IIP3, distortion characteristics (HD2, HD3), 1- dB the compression point, delay and power delay product performancehave also been throughly studied.It has been observed that the device features discussed for circuitry applications are found to be sensitiveto of gate materials, design configuration and input signals.

Tunnel FETisone of thealternativedevicefor low power electronics having steep subthreshold swing and lower leakage current than conventional MOSFET. In this research work, we have implemented the idea of high -k gate dielectric ondouble gate Tunnel FET, DG-TFETfor improvement of device features.An extensive investigation for the analog/RF and linearity feature of DG-TFET has been donehere for low power circuit and system development.Several essential analog/RF and linearity parameters like transconductance(gm), transconductance generation factor (gm/IDS) its high-order derivatives (gm2, gm3), cut-off frequency (fT), gain band width product (GBW), transconductance generation factor (gm/IDS) has been investigated for low power RF applications.The VIP2, VIP3, IMD3, IIP3, distortion characteristics (HD2, HD3), 1- dB the compression point, delay and power delay product performancehave also been throughly studied.It has been observed that the device features discussed for circuitry applications are found to be sensitiveto of gate materials, design configuration and input signals.