The present study aimed to investigate the potential protective effects of zinc (Zn) against hexavalent chromium-induced hepatotoxicity in pregnant Wistar rats. Female rats were treated subcutaneously (s.c) on the 3 rd day of pregnancy, with NaCl 0.9 % and served as control, K₂Cr₂O7 (10 mg/kg bw) alone, or K₂Cr₂O7 in association with ZnCl2 (20 mg/kg bw). Hepatic biochemical parameters, oxidative stress biomarkers and DNA damage were monitored. Results revealed that K₂Cr₂O7 disturbed plasma ALT, AST, ALP and GGT, induced hepatic oxidative stress and DNA fragmentation. The co-treatment with Zn has alleviated K2Cr2O7-induced hepatotoxicity by exhibiting antioxidant and genoprotective effects in pregnant Wistar rats.

The present study aimed to investigate the potential protective effects of zinc (Zn) against hexavalent chromium-induced hepatotoxicity in pregnant Wistar rats. Female rats were treated subcutaneously (s.c) on the 3 rd day of pregnancy, with NaCl 0.9 % and served as control, K₂Cr₂O7 (10 mg/kg bw) alone, or K₂Cr₂O7 in association with ZnCl2 (20 mg/kg bw). Hepatic biochemical parameters, oxidative stress biomarkers and DNA damage were monitored. Results revealed that K₂Cr₂O7 disturbed plasma ALT, AST, ALP and GGT, induced hepatic oxidative stress and DNA fragmentation. The co-treatment with Zn has alleviated K2Cr2O7-induced hepatotoxicity by exhibiting antioxidant and genoprotective effects in pregnant Wistar rats.

The present study aimed to investigate the potential protective effects of zinc (Zn) against hexavalent chromium-induced hepatotoxicity in pregnant Wistar rats. Female rats were treated subcutaneously (s.c) on the 3 rd day of pregnancy, with NaCl 0.9 % and served as control, K₂Cr₂O7 (10 mg/kg bw) alone, or K₂Cr₂O7 in association with ZnCl2 (20 mg/kg bw). Hepatic biochemical parameters, oxidative stress biomarkers and DNA damage were monitored. Results revealed that K₂Cr₂O7 disturbed plasma ALT, AST, ALP and GGT, induced hepatic oxidative stress and DNA fragmentation. The co-treatment with Zn has alleviated K2Cr2O7-induced hepatotoxicity by exhibiting antioxidant and genoprotective effects in pregnant Wistar rats.

The present study aimed to investigate the potential protective effects of zinc (Zn) against hexavalent chromium-induced hepatotoxicity in pregnant Wistar rats. Female rats were treated subcutaneously (s.c) on the 3 rd day of pregnancy, with NaCl 0.9 % and served as control, K₂Cr₂O7 (10 mg/kg bw) alone, or K₂Cr₂O7 in association with ZnCl2 (20 mg/kg bw). Hepatic biochemical parameters, oxidative stress biomarkers and DNA damage were monitored. Results revealed that K₂Cr₂O7 disturbed plasma ALT, AST, ALP and GGT, induced hepatic oxidative stress and DNA fragmentation. The co-treatment with Zn has alleviated K2Cr2O7-induced hepatotoxicity by exhibiting antioxidant and genoprotective effects in pregnant Wistar rats.

Some epidemiological situations, because of their magnitude and their propagation dynamics, can escape local or national control. For example, the world is currently experiencing an uncontrollable cross-border spread of the corona virus (Covid-19). The Wilaya of Batna is among the most affected in Algeria by many epidemiological diseases, including tuberculosis, which raises questions about possible causal links between this contagious and often fatal disease and the environmental and socio-economic reality of this territory. We based our study on a number of factors, covering economic, societal and health aspects, which constitute indicators of the standard of living in each of the 61 communes of the Wilaya of Batna. The relationship between the epidemiological status of tuberculosis in these communes and these indicators showed significant correlations and thus confirmed the reliability of the choice of parameters of vulnerability to tuberculosis. To understand their interaction and impact on the disease and its spatial distribution, we used the hierarchical multicriteria analysis (AHP) method, the results of which were implemented in a GIS database. The aim was to provide health and territorial decision makers with a decision support tool. The results show that the spatial distribution of tuberculosis cases which reappeared in the Wilaya of Batna after its eradication since years is in good correlation with the socio-economic situation of each commune of the territory and confirm that this scourge of tuberculosis is closely linked to the degradation of the living conditions of the inhabitants.

Some epidemiological situations, because of their magnitude and their propagation dynamics, can escape local or national control. For example, the world is currently experiencing an uncontrollable cross-border spread of the corona virus (Covid-19). The Wilaya of Batna is among the most affected in Algeria by many epidemiological diseases, including tuberculosis, which raises questions about possible causal links between this contagious and often fatal disease and the environmental and socio-economic reality of this territory. We based our study on a number of factors, covering economic, societal and health aspects, which constitute indicators of the standard of living in each of the 61 communes of the Wilaya of Batna. The relationship between the epidemiological status of tuberculosis in these communes and these indicators showed significant correlations and thus confirmed the reliability of the choice of parameters of vulnerability to tuberculosis. To understand their interaction and impact on the disease and its spatial distribution, we used the hierarchical multicriteria analysis (AHP) method, the results of which were implemented in a GIS database. The aim was to provide health and territorial decision makers with a decision support tool. The results show that the spatial distribution of tuberculosis cases which reappeared in the Wilaya of Batna after its eradication since years is in good correlation with the socio-economic situation of each commune of the territory and confirm that this scourge of tuberculosis is closely linked to the degradation of the living conditions of the inhabitants.

In the last decade, the number of diabetic persons has considerably increased and the scientific community approach to understand this complex pathology has become very difficult due to the fact that diabetes is linked to other illnesses which can generate serious complications like glaucoma, nerve damage. Plants are considered new alternative resources to treat various pathologies including type 2 diabetes, and several research works showed that it is significantly more accurate to use Oral Glucose Tolerance Test (OGTT) when diagnosing diabetes which prompted us to adopt this model to evaluate the possible anti-hyperglycemic effect of n-BuOH extract of Centaurea tougourensis. More than 500 Centaurea species are distributed in Mediterranean and West Asia zones. These species demonstrated over the years their pharmacological potential like antioxidant, anti-microbial, anti-diabetic, cytotoxic, activities due to their richness in secondary metabolites. A Preliminary phytoscreening was first done to identify the most important secondary metabolites in the plant and revealed the presence of key classes like; tannins, flavonoids, triterpenes… The pre-treatment of mice group by the dose of (400 ml/kg, p.o) of plant extract resulted in a significant (P<0.01) decrease of hyperglycemia (1.32 ± 0.06 g/l) 60 min after the induction of a temporary diabetes with a maximum percentage inhibition of (37%) while the reference group treated by Glibenclamide (10 mg/kg, i.p.) was only (31%) the same time. This concluded that C. tougourensis stabilized the blood glucose level and may have the potential to treat other pathologies.

In the last decade, the number of diabetic persons has considerably increased and the scientific community approach to understand this complex pathology has become very difficult due to the fact that diabetes is linked to other illnesses which can generate serious complications like glaucoma, nerve damage. Plants are considered new alternative resources to treat various pathologies including type 2 diabetes, and several research works showed that it is significantly more accurate to use Oral Glucose Tolerance Test (OGTT) when diagnosing diabetes which prompted us to adopt this model to evaluate the possible anti-hyperglycemic effect of n-BuOH extract of Centaurea tougourensis. More than 500 Centaurea species are distributed in Mediterranean and West Asia zones. These species demonstrated over the years their pharmacological potential like antioxidant, anti-microbial, anti-diabetic, cytotoxic, activities due to their richness in secondary metabolites. A Preliminary phytoscreening was first done to identify the most important secondary metabolites in the plant and revealed the presence of key classes like; tannins, flavonoids, triterpenes… The pre-treatment of mice group by the dose of (400 ml/kg, p.o) of plant extract resulted in a significant (P<0.01) decrease of hyperglycemia (1.32 ± 0.06 g/l) 60 min after the induction of a temporary diabetes with a maximum percentage inhibition of (37%) while the reference group treated by Glibenclamide (10 mg/kg, i.p.) was only (31%) the same time. This concluded that C. tougourensis stabilized the blood glucose level and may have the potential to treat other pathologies.

In the last decade, the number of diabetic persons has considerably increased and the scientific community approach to understand this complex pathology has become very difficult due to the fact that diabetes is linked to other illnesses which can generate serious complications like glaucoma, nerve damage. Plants are considered new alternative resources to treat various pathologies including type 2 diabetes, and several research works showed that it is significantly more accurate to use Oral Glucose Tolerance Test (OGTT) when diagnosing diabetes which prompted us to adopt this model to evaluate the possible anti-hyperglycemic effect of n-BuOH extract of Centaurea tougourensis. More than 500 Centaurea species are distributed in Mediterranean and West Asia zones. These species demonstrated over the years their pharmacological potential like antioxidant, anti-microbial, anti-diabetic, cytotoxic, activities due to their richness in secondary metabolites. A Preliminary phytoscreening was first done to identify the most important secondary metabolites in the plant and revealed the presence of key classes like; tannins, flavonoids, triterpenes… The pre-treatment of mice group by the dose of (400 ml/kg, p.o) of plant extract resulted in a significant (P<0.01) decrease of hyperglycemia (1.32 ± 0.06 g/l) 60 min after the induction of a temporary diabetes with a maximum percentage inhibition of (37%) while the reference group treated by Glibenclamide (10 mg/kg, i.p.) was only (31%) the same time. This concluded that C. tougourensis stabilized the blood glucose level and may have the potential to treat other pathologies.