Purpose The purpose of this paper is to achieve the national strategic agenda’s criteria that aim for accomplishing sustainable buildings by estimating the effects of energy efficiency measures in order to reduce energy consumption and CO2 emission. Design/methodology/approach A design approach has been developed based on simulation software and a modeled building. Therefore, a typical office building is considered for testing five efficiency measures in three climatic conditions in Algeria. This approach is conducted in two phases: first, the analysis of each measure’s effect is independently carried out in terms of cooling energy and heating energy intensities. Then, a combination of optimal measures for each climate zone is measured in terms of three sustainable indicators: final energy consumption, energy cost saving and CO2 emission. Findings The results reveal that a combination of optimal measures has a substantial impact on building energy saving and CO2 emission. This saving can rise to 41 and 31 percent in a hot and cold climate, respectively. Furthermore, it is concluded that obtaining higher building performance, different design alternatives should be adapted to the climate proprieties and the local construction materials must be applied. Originality/value This study is considered as an opportunity for achieving the national strategy, as it may contribute in improving office building performance and demonstrating a suitable tool to assist stakeholders in the decision making of most important parameters in the design stage for new or retrofit buildings.