This paper investigates capacity planning with outsourcing under reliability-maintenance constraints. The considered supply-chain consists of a single-manufacturer and multiple-subcontractors. The manufacturer's company is composed of a single unit subject to random failures. Corrective maintenance is endorsed when failures occur, and preventive maintenance can be carried out to reduce the degradation. The high in-house costs and the incapacity motivate the manufacturer outsourcing to independent subcontractors. In addition, based on the principle of comparative advantage, the manufacturer balances between in-house capacities and outsourcing services, which minimises the total cost. The aim is to propose a new policy based on the combination between integrated-maintenance and outsourcing policies. A mathematical model and an optimisation procedure have been developed in order to determine the best in-house production-maintenance and outsourcing plans for the manufacturer while minimising the total cost. In order to show the applicability of our approach, we conduct experimentations to study the management insights.

This paper investigates capacity planning with outsourcing under reliability-maintenance constraints. The considered supply-chain consists of a single-manufacturer and multiple-subcontractors. The manufacturer's company is composed of a single unit subject to random failures. Corrective maintenance is endorsed when failures occur, and preventive maintenance can be carried out to reduce the degradation. The high in-house costs and the incapacity motivate the manufacturer outsourcing to independent subcontractors. In addition, based on the principle of comparative advantage, the manufacturer balances between in-house capacities and outsourcing services, which minimises the total cost. The aim is to propose a new policy based on the combination between integrated-maintenance and outsourcing policies. A mathematical model and an optimisation procedure have been developed in order to determine the best in-house production-maintenance and outsourcing plans for the manufacturer while minimising the total cost. In order to show the applicability of our approach, we conduct experimentations to study the management insights.

This paper investigates capacity planning with outsourcing under reliability-maintenance constraints. The considered supply-chain consists of a single-manufacturer and multiple-subcontractors. The manufacturer's company is composed of a single unit subject to random failures. Corrective maintenance is endorsed when failures occur, and preventive maintenance can be carried out to reduce the degradation. The high in-house costs and the incapacity motivate the manufacturer outsourcing to independent subcontractors. In addition, based on the principle of comparative advantage, the manufacturer balances between in-house capacities and outsourcing services, which minimises the total cost. The aim is to propose a new policy based on the combination between integrated-maintenance and outsourcing policies. A mathematical model and an optimisation procedure have been developed in order to determine the best in-house production-maintenance and outsourcing plans for the manufacturer while minimising the total cost. In order to show the applicability of our approach, we conduct experimentations to study the management insights.

Antibiotic resistance is one of the greatest public-health challenges worldwide, especially with regard to Gram-negative bacteria (GNB). Carbapenems are the β-lactam antibiotics of choice with the broadest spectrum of activity and, in many cases, are the last-resort treatment for several bacterial infections. Carbapenemase-encoding genes, mainly carried by mobile genetic elements, are the main mechanism of resistance against carbapenems in GNB. These enzymes exhibit a versatile hydrolytic capacity and confer resistance to most β-lactam antibiotics. After being considered a clinical issue, increasing attention is being giving to the dissemination of such resistance mechanisms in the environment and especially through water. Aquatic environments are among the most significant microbial habitats on our planet, known as a favourable medium for antibiotic gene transfer, and they play a crucial role in the huge spread of drug resistance in the environment and the community. In this review, we present current knowledge regarding the spread of carbapenemase-producing isolates in different aquatic environments, which may help the implementation of control and prevention strategies against the spread of such dangerous resistant agents in the environment.

Antibiotic resistance is one of the greatest public-health challenges worldwide, especially with regard to Gram-negative bacteria (GNB). Carbapenems are the β-lactam antibiotics of choice with the broadest spectrum of activity and, in many cases, are the last-resort treatment for several bacterial infections. Carbapenemase-encoding genes, mainly carried by mobile genetic elements, are the main mechanism of resistance against carbapenems in GNB. These enzymes exhibit a versatile hydrolytic capacity and confer resistance to most β-lactam antibiotics. After being considered a clinical issue, increasing attention is being giving to the dissemination of such resistance mechanisms in the environment and especially through water. Aquatic environments are among the most significant microbial habitats on our planet, known as a favourable medium for antibiotic gene transfer, and they play a crucial role in the huge spread of drug resistance in the environment and the community. In this review, we present current knowledge regarding the spread of carbapenemase-producing isolates in different aquatic environments, which may help the implementation of control and prevention strategies against the spread of such dangerous resistant agents in the environment.

Antibiotic resistance is one of the greatest public-health challenges worldwide, especially with regard to Gram-negative bacteria (GNB). Carbapenems are the β-lactam antibiotics of choice with the broadest spectrum of activity and, in many cases, are the last-resort treatment for several bacterial infections. Carbapenemase-encoding genes, mainly carried by mobile genetic elements, are the main mechanism of resistance against carbapenems in GNB. These enzymes exhibit a versatile hydrolytic capacity and confer resistance to most β-lactam antibiotics. After being considered a clinical issue, increasing attention is being giving to the dissemination of such resistance mechanisms in the environment and especially through water. Aquatic environments are among the most significant microbial habitats on our planet, known as a favourable medium for antibiotic gene transfer, and they play a crucial role in the huge spread of drug resistance in the environment and the community. In this review, we present current knowledge regarding the spread of carbapenemase-producing isolates in different aquatic environments, which may help the implementation of control and prevention strategies against the spread of such dangerous resistant agents in the environment.

Antibiotic resistance is one of the greatest public-health challenges worldwide, especially with regard to Gram-negative bacteria (GNB). Carbapenems are the β-lactam antibiotics of choice with the broadest spectrum of activity and, in many cases, are the last-resort treatment for several bacterial infections. Carbapenemase-encoding genes, mainly carried by mobile genetic elements, are the main mechanism of resistance against carbapenems in GNB. These enzymes exhibit a versatile hydrolytic capacity and confer resistance to most β-lactam antibiotics. After being considered a clinical issue, increasing attention is being giving to the dissemination of such resistance mechanisms in the environment and especially through water. Aquatic environments are among the most significant microbial habitats on our planet, known as a favourable medium for antibiotic gene transfer, and they play a crucial role in the huge spread of drug resistance in the environment and the community. In this review, we present current knowledge regarding the spread of carbapenemase-producing isolates in different aquatic environments, which may help the implementation of control and prevention strategies against the spread of such dangerous resistant agents in the environment.

The Reynolds–averaged Navier–Stokes (RANS) equations were solved along with Reynolds stress model (RSM), to study the fully-developed unsteady and anisotropic single-phase turbulent flow in 90° bend pipe with circular cross-section. Two flow configurations are considered the first is without ribs and the second is with ribs attached to solid walls. The number of ribs is 14 ribs regularly placed along the straight pipe. The pitch ratios is 40 and the rib height e (mm) is 10% of the pipe diameter. Both bends have a curvature radius ratio, of 2.0. The solutions of these flows were obtained using the commercial CFD software Fluent at a Dean number range from 5000 to 40000. In order to validate the turbulence model, numerical simulations were compared with the existing experimental data. The results are found in good agreement with the literature data. After validation of the numerical strategy, the axial velocity distribution and the anisotropy of the Reynolds stresses at several downstream longitudinal locations were obtained in order to investigate the hydrodynamic developments of the analyzed flow. The results show that in the ribbed bend pipe, the maximum velocity value is approximately 47% higher than the corresponding upstream value but it is 9% higher in the case of the bend pipe without ribs. It was also found for both cases that the distribution of the mean axial velocity depends faintly on the Dean number. Finally, it can be seen that the analyzed flow in the bend pipe without ribs appears more anisotropic than in bend pipe with ribs.

The Reynolds–averaged Navier–Stokes (RANS) equations were solved along with Reynolds stress model (RSM), to study the fully-developed unsteady and anisotropic single-phase turbulent flow in 90° bend pipe with circular cross-section. Two flow configurations are considered the first is without ribs and the second is with ribs attached to solid walls. The number of ribs is 14 ribs regularly placed along the straight pipe. The pitch ratios is 40 and the rib height e (mm) is 10% of the pipe diameter. Both bends have a curvature radius ratio, of 2.0. The solutions of these flows were obtained using the commercial CFD software Fluent at a Dean number range from 5000 to 40000. In order to validate the turbulence model, numerical simulations were compared with the existing experimental data. The results are found in good agreement with the literature data. After validation of the numerical strategy, the axial velocity distribution and the anisotropy of the Reynolds stresses at several downstream longitudinal locations were obtained in order to investigate the hydrodynamic developments of the analyzed flow. The results show that in the ribbed bend pipe, the maximum velocity value is approximately 47% higher than the corresponding upstream value but it is 9% higher in the case of the bend pipe without ribs. It was also found for both cases that the distribution of the mean axial velocity depends faintly on the Dean number. Finally, it can be seen that the analyzed flow in the bend pipe without ribs appears more anisotropic than in bend pipe with ribs.

The Reynolds–averaged Navier–Stokes (RANS) equations were solved along with Reynolds stress model (RSM), to study the fully-developed unsteady and anisotropic single-phase turbulent flow in 90° bend pipe with circular cross-section. Two flow configurations are considered the first is without ribs and the second is with ribs attached to solid walls. The number of ribs is 14 ribs regularly placed along the straight pipe. The pitch ratios is 40 and the rib height e (mm) is 10% of the pipe diameter. Both bends have a curvature radius ratio, of 2.0. The solutions of these flows were obtained using the commercial CFD software Fluent at a Dean number range from 5000 to 40000. In order to validate the turbulence model, numerical simulations were compared with the existing experimental data. The results are found in good agreement with the literature data. After validation of the numerical strategy, the axial velocity distribution and the anisotropy of the Reynolds stresses at several downstream longitudinal locations were obtained in order to investigate the hydrodynamic developments of the analyzed flow. The results show that in the ribbed bend pipe, the maximum velocity value is approximately 47% higher than the corresponding upstream value but it is 9% higher in the case of the bend pipe without ribs. It was also found for both cases that the distribution of the mean axial velocity depends faintly on the Dean number. Finally, it can be seen that the analyzed flow in the bend pipe without ribs appears more anisotropic than in bend pipe with ribs.

The Reynolds–averaged Navier–Stokes (RANS) equations were solved along with Reynolds stress model (RSM), to study the fully-developed unsteady and anisotropic single-phase turbulent flow in 90° bend pipe with circular cross-section. Two flow configurations are considered the first is without ribs and the second is with ribs attached to solid walls. The number of ribs is 14 ribs regularly placed along the straight pipe. The pitch ratios is 40 and the rib height e (mm) is 10% of the pipe diameter. Both bends have a curvature radius ratio, of 2.0. The solutions of these flows were obtained using the commercial CFD software Fluent at a Dean number range from 5000 to 40000. In order to validate the turbulence model, numerical simulations were compared with the existing experimental data. The results are found in good agreement with the literature data. After validation of the numerical strategy, the axial velocity distribution and the anisotropy of the Reynolds stresses at several downstream longitudinal locations were obtained in order to investigate the hydrodynamic developments of the analyzed flow. The results show that in the ribbed bend pipe, the maximum velocity value is approximately 47% higher than the corresponding upstream value but it is 9% higher in the case of the bend pipe without ribs. It was also found for both cases that the distribution of the mean axial velocity depends faintly on the Dean number. Finally, it can be seen that the analyzed flow in the bend pipe without ribs appears more anisotropic than in bend pipe with ribs.

In this study, an efficient full-wave method is developed for characterizing the resonant frequencies, bandwidths, and quality factors of an inverted circular superconducting patch antenna. Our technique is based on the Galerkin procedure in the Hankel transform domain (HTD) combined with the complex resistive boundary conditions. With the use of suitable Green’s functions in the HTD, the analysis is performed for the case where the superconducting circular patches is printed on an anisotropic substrate. The numerical results obtained using this approach are compared with the experimental results. These comparisons were very good, which proves the correctness and the validity of the method. It is found that the optical properties combined with optimally-chosen structural parameters of anisotropic materials can maintain control of the resonant frequency and exhibit wider bandwidth characteristics.

In this study, an efficient full-wave method is developed for characterizing the resonant frequencies, bandwidths, and quality factors of an inverted circular superconducting patch antenna. Our technique is based on the Galerkin procedure in the Hankel transform domain (HTD) combined with the complex resistive boundary conditions. With the use of suitable Green’s functions in the HTD, the analysis is performed for the case where the superconducting circular patches is printed on an anisotropic substrate. The numerical results obtained using this approach are compared with the experimental results. These comparisons were very good, which proves the correctness and the validity of the method. It is found that the optical properties combined with optimally-chosen structural parameters of anisotropic materials can maintain control of the resonant frequency and exhibit wider bandwidth characteristics.

In this study, an efficient full-wave method is developed for characterizing the resonant frequencies, bandwidths, and quality factors of an inverted circular superconducting patch antenna. Our technique is based on the Galerkin procedure in the Hankel transform domain (HTD) combined with the complex resistive boundary conditions. With the use of suitable Green’s functions in the HTD, the analysis is performed for the case where the superconducting circular patches is printed on an anisotropic substrate. The numerical results obtained using this approach are compared with the experimental results. These comparisons were very good, which proves the correctness and the validity of the method. It is found that the optical properties combined with optimally-chosen structural parameters of anisotropic materials can maintain control of the resonant frequency and exhibit wider bandwidth characteristics.

In this study, an efficient full-wave method is developed for characterizing the resonant frequencies, bandwidths, and quality factors of an inverted circular superconducting patch antenna. Our technique is based on the Galerkin procedure in the Hankel transform domain (HTD) combined with the complex resistive boundary conditions. With the use of suitable Green’s functions in the HTD, the analysis is performed for the case where the superconducting circular patches is printed on an anisotropic substrate. The numerical results obtained using this approach are compared with the experimental results. These comparisons were very good, which proves the correctness and the validity of the method. It is found that the optical properties combined with optimally-chosen structural parameters of anisotropic materials can maintain control of the resonant frequency and exhibit wider bandwidth characteristics.

This paper presents an experimental study to evaluate the effect of local mineral additions (pozzolan, slag and limestone) on the rheological behaviour of based cement binder’s pastes. The binary, ternary and quaternary binder pastes were prepared with the partial clinker cement replacement limited up to 20%, according with type CEM II specifications. The cements were characterized by their geometric shapes, the reactivity and the chemical composition. An experimental design plan was used to modelling the rheological behaviour of pastes. The relatives yield stress and plastic viscosity of binder’s pastes, with normal consistency, were determined. The results showed that all the tested compositions with additions follow the same rheological behaviour law according to the Bingham model. The binder pastes rheological parameters (yield stress and viscosity) are affected by mineral additions. The highest values of the rheological parameters were measured in binary and ternary cements with limestone and pozzolan. On the other hand, the lower viscosity among the tested pastes was obtained with slag addition. The statistical approach allowed us to obtain a satisfactory modelling of viscosity and yield stress with a coefficient of determination R² = 0.91 and 0.92, respectively and a satisfactory correlation between the viscosity and the water/binder ratio (W/B) for a normal consistency with a coefficient of determination R² = 0.91.

This paper presents an experimental study to evaluate the effect of local mineral additions (pozzolan, slag and limestone) on the rheological behaviour of based cement binder’s pastes. The binary, ternary and quaternary binder pastes were prepared with the partial clinker cement replacement limited up to 20%, according with type CEM II specifications. The cements were characterized by their geometric shapes, the reactivity and the chemical composition. An experimental design plan was used to modelling the rheological behaviour of pastes. The relatives yield stress and plastic viscosity of binder’s pastes, with normal consistency, were determined. The results showed that all the tested compositions with additions follow the same rheological behaviour law according to the Bingham model. The binder pastes rheological parameters (yield stress and viscosity) are affected by mineral additions. The highest values of the rheological parameters were measured in binary and ternary cements with limestone and pozzolan. On the other hand, the lower viscosity among the tested pastes was obtained with slag addition. The statistical approach allowed us to obtain a satisfactory modelling of viscosity and yield stress with a coefficient of determination R² = 0.91 and 0.92, respectively and a satisfactory correlation between the viscosity and the water/binder ratio (W/B) for a normal consistency with a coefficient of determination R² = 0.91.

This paper presents an experimental study to evaluate the effect of local mineral additions (pozzolan, slag and limestone) on the rheological behaviour of based cement binder’s pastes. The binary, ternary and quaternary binder pastes were prepared with the partial clinker cement replacement limited up to 20%, according with type CEM II specifications. The cements were characterized by their geometric shapes, the reactivity and the chemical composition. An experimental design plan was used to modelling the rheological behaviour of pastes. The relatives yield stress and plastic viscosity of binder’s pastes, with normal consistency, were determined. The results showed that all the tested compositions with additions follow the same rheological behaviour law according to the Bingham model. The binder pastes rheological parameters (yield stress and viscosity) are affected by mineral additions. The highest values of the rheological parameters were measured in binary and ternary cements with limestone and pozzolan. On the other hand, the lower viscosity among the tested pastes was obtained with slag addition. The statistical approach allowed us to obtain a satisfactory modelling of viscosity and yield stress with a coefficient of determination R² = 0.91 and 0.92, respectively and a satisfactory correlation between the viscosity and the water/binder ratio (W/B) for a normal consistency with a coefficient of determination R² = 0.91.

This paper presents an experimental study to evaluate the effect of local mineral additions (pozzolan, slag and limestone) on the rheological behaviour of based cement binder’s pastes. The binary, ternary and quaternary binder pastes were prepared with the partial clinker cement replacement limited up to 20%, according with type CEM II specifications. The cements were characterized by their geometric shapes, the reactivity and the chemical composition. An experimental design plan was used to modelling the rheological behaviour of pastes. The relatives yield stress and plastic viscosity of binder’s pastes, with normal consistency, were determined. The results showed that all the tested compositions with additions follow the same rheological behaviour law according to the Bingham model. The binder pastes rheological parameters (yield stress and viscosity) are affected by mineral additions. The highest values of the rheological parameters were measured in binary and ternary cements with limestone and pozzolan. On the other hand, the lower viscosity among the tested pastes was obtained with slag addition. The statistical approach allowed us to obtain a satisfactory modelling of viscosity and yield stress with a coefficient of determination R² = 0.91 and 0.92, respectively and a satisfactory correlation between the viscosity and the water/binder ratio (W/B) for a normal consistency with a coefficient of determination R² = 0.91.

The current study focuses on the chemical composition, and evaluation of antioxidant and antibacterial activity of the aerial parts of Centaurea resupinata subsp. dufourii. Using different chromatographic methods nine compounds 1–9 were isolated. The structural identification of isolated compounds was achieved using several spectroscopic methods NMR techniques (1H NMR, 13C NMR, COSY, HSQC, HMBC) and mass spectroscopy (ESI-MS) and by comparison with literature data. The structures of these compounds were identified as nicotiflorin (1), apigetrin (2), chrysoeriol (3), apigenin (4), chrysin (5), daucosterol (6), β-sitosterol (7), taraxastrerol (8) and lupeol (9). The antibacterial and antioxidant activities of ethyl acetate and n-butanol extracts have been evaluated. The antioxidant activity was assessed in vitro using DPPH radical scavenging method, which showed that ethyl acetate extract possessed an interesting antioxidant potential (IC50 = 36.263 ± 0.005 μg/mL).