Context: This is the first study on the phytochemistry, antioxidant, anticholinesterase, and antibacterial activities of Sedum caeruleum L. (Crassulaceae). Objective: The objective of this study is to isolate the secondary metabolites and determine the antioxidant, anticholinesterase, and antibacterial activities of S. caeruleum. Materials and methods: Six compounds (1–6) were isolated from the extracts of S. caeruleum and elucidated using UV, 1D-, 2D-NMR, and MS techniques. Antioxidant activity was investigated using DPPH•, CUPRAC, and ferrous-ions chelating assays. Anticholinesterase activity was determined against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes using the Ellman method. Antibacterial activity was performed according to disc diffusion and minimum inhibitory concentration (MIC) methods. Results: Isolated compounds were elucidated as ursolic acid (1), daucosterol (2), β-sitosterol-3-O-β-d-galactopyranoside (3), apigenin (4), apigetrin (5), and apiin (6). The butanol extract exhibited highest antioxidant activity in all tests (IC50 value: 28.35 ± 1.22 µg/mL in DPPH assay, IC50 value: 40.83 ± 2.24 µg/L in metal chelating activity, and IC50value: 23.52 ± 0.44 µg/L in CUPRAC), and the highest BChE inhibitory activity (IC50 value: 36.89 ± 0.15 µg/L). Moreover, the chloroform extract mildly inhibited (MIC value: 80 µg/mL) the growth of all the tested bacterial strains. Discussion and conclusion: Ursolic acid (1), daucosterol (2), β-sitosterol-3-O-β-d-galactopyranoside (3), apigenin (4), apigetrin (5), and apiin (6) were isolated from Sedum caeruleum for the first time. In addition, a correlation was observed between antioxidant and anticholinesterase activities of bioactive ingredients of this plant.

This article deals with the study of a new swimming microrobot behavior using an analytical investigation. The analyzed microrobot is associated by a spherical head and hybrid tail. The principle of modeling is based on solving of the coupled elastic/fluidic problems between the hybrid tail’s deflections and the running environment. In spite of the resulting nonlinear model can be exploited to enhance both the sailing ability and also can be controlled in viscous environment using nonlinear control investigations. The applications of the micro-robot have required the precision of control for targeting the running area in terms of response time and tracking error. Due to these limitations, the Flatness-ANFIS based control is used to ensure a good control behavior in hazardous environment. Our control investigation is coupled the differential flatness and adaptive neuro-fuzzy inference techniques, in which the flatness is used to planning the optimal trajectory and eliminate the nonlinearity effects of the resulting model. In other hand, the neuro-fuzzy inference technique is used to build the law of control technique and minimize the dynamic error of tracking trajectory. In particular, we deduct from a non linear model to an optimal model of the design parameter’s using Multi-Objective genetic algorithms (MOGAs). In addition, Computational fluid dynamics modeling of the microrobot is also carried out to study the produced thrust and velocity of the microrobot displacement taking into account the fluid parameters. Our analytical results have been validated by the recorded good agreement between the numerical and analytical results.

Investigation on oil reservoirs is up to several approaches under different aspects. oilreservoir is dependent on several approaches in different aspects. Distinct settings may be considered for the qualitative and quantitative reservoir evaluation. Control on potential reservoir accumulation is related to permeability and poroslty, in addition to diagenetic and petrographic effects. ln the case study, the considered reservoir is dealing with Cretaceous Carbonate series of ConiacianSantonian age located in the South East of Constantine area (Sud-Est Constontinois). From exploration and evaluation point of view, the oil potential, in the cited area levels, remains almost unexplored. Based on logging and drilling collected data indicates that the approached level of Coniancian -Santonian age can be a tight type. Evidences is from the permeability which is ranging from 0.1 md to 50 md and porosity stretching from lYo up to 16%o. Thus, contribution of tectonic effect is minimized. In the same harmony is the diagenetic and petrographic attitude which is responsible for the compaction and lesser dissolution with occlusion mostly of the intergranular.

Background: Diffuse Large B Cell Lymphoma (DLBCL) is the most common form of aggressive non-Hodgkin’s lymphoma (NHL) accounting for approximately 40 % of all NHL cases. The aim of our study is to carry out an epidemiologic description and to compute the incidence of DLBCL in 2North African countries, Algeria and Tunisia. Patients and methods: This is a multicenter retrospective and descriptive study, covering a period of 5 years (January 2010 - December 2014), carried out in 17 centers in Algeria and 5 centers in Tunisia. Patients aged less than 15 years were excluded. We used the classification of World Health Organization. We used Epi info 6 software to analyze the data. Results: 1432 cases were identified, 1175 in Algeria and 257 in Tunisia. The sex distribution of DLBCL was as follows: males 837 (58.4 %), females 591 (41.6 %), male-to-female ratio 1.40. The age of patients ranged from 16 to 96 years (median 52 years) and 64.2 % of the patients are less than 60. The incidence estimates for the years 2012 and 2013 are respectively 0.86 and 0.87 for 100,000 inhabitants. The most frequent occupation of the cases is farmworker (11.5%). The average time between the date of diagnosis and clinical examination is 31 days. The average delay between the first clinical sign and the date of diagnosis is 133 days. A familial history of cancer is found in 10% of the cases. The lymph node biopsy was undertaken in 30.7% of the cases in the cervical area and in 15% of cases in the mediastinal area. A reexamination of the slides was undertaken in 20% of cases while 61.6% of them were found to be advanced clinical stages (III + IV). Splenomegaly was found in 16% of the cases and hepatomegaly in 7%. ORL damage was found in 16% of the cases and marrow infiltration in 10.2%. A Prognostic Score IPI >= 2 is found in 38% of the patients. Comments: On a previous Algerian study concerning all lymphomas diagnosed over a period of 6 years (2007-2012) (Journal of Hematology No. 10-11, 2015), 485 new cases of lymphoma were diagnosed on average per year. In the present study, the average number of new cases of DLBCL was 235 and the average proportion was 48% of all lymphomas. It should be emphasized that all cases underwent an immunohistochemical study and that lymphatic cases were excluded (digestive, bone, skin). The national incidence rate is low compared to that of international studies, a fact that is probably due to difficulties in the diagnosis including lack of implementation of immunohistochemistry techniques in our region. Disclosures No relevant conflicts of interest to declare.

Purpose – Ballast water of merchant ship is a source of introduction of invasive species around the globe. The purpose of this paper is to present a quantitative risk assessment applied to a model port, the Port of Arzew in Algeria, and based on an analysis of this port’s shipping traffic. Design/methodology/approach – The risk assessment for introduction of invasive species is interpreted in the form of a probabilistic process, with a combination of two probabilities. The first probability is related to the ability of a species to arrive to the destination (recipient port), depending on the quantity of water ballast discharged and the duration of voyage. The second one is based on the species ability to survive in their new environment, which depends on the environmental similarity between donor port and Arzew port. Findings – This assessment’s outcome consists on a classification of scenarios regarding their acceptability. Consequently, it helped to classify donor ports according to a risk scale, from low risk to high-risk donor ports. Research limitations/implications – The phenomenon of invasion of aquatic species is a complex process. Factors such as adaptation and tolerance of species, the attendance or absence of predators, were not taken into account in this study. Practical implications – This study could be used by the maritime administration as a decision-making tool regarding the issue of exemptions under the IMO International Convention on the Management of Ballast Water and Sediments 2004. Originality/value – This is one of the first known studies in Algeria and dealing with ballast water management. The results of this assessment provide useful information to policy makers, in order to develop a national strategy to reduce the impact of shipping pollution on the marine environment.

In this paper, new sensors based on a double-gate (DG) graphene nanoribbon field-effect transistor (GNRFET), for high-performance DNA and gas detection, are proposed through a simulation-based study. The proposed sensors are simulated by solving the Schrödinger equation using the mode space non-equilibrium Green’s function formalism coupled self-consistently with a 2D Poisson equation under the ballistic limits. The dielectric and work function modulation techniques are used for the electrical detection of DNA and gas molecules, respectively. The behaviors of both the sensors have been investigated, and the impacts of variation in geometrical and electrical parameters on the sensitivity of sensors have also been studied. In comparison to other FET-based sensors, the proposed sensors provide not only higher sensitivity but also better electrical and scaling performances. The obtained results make the proposed DG-GNRFET-based sensors as promising candidates for ultra-sensitive, small-size, low-power and reliable CMOS-based DNA, and gas sensors.