Clinical heterogeneity is often due to genetic heterogeneity. One mechanism by which different mutations can produce a phenotypic variation). Beta-thalassemia is mainly caused by a large number of mutations of the gene for beta-globin. The objective of this study is to correlate molecular lesions and clinical signs in children with beta-thalassemia homozygous. We carried out the molecular genetics of beta globin gene by the method of mini sequencing using Snapshot ™ kit (Applied Biosystems) in search of the mutation codon 39 (C>T) (HBB: c.118C>T) and we studied haematological parameters by statistical method using the test “t” of Student for comparing the means of the samples. The peripheral blood smear examination was done from the slides stained in Wright stains. The results obtained have shown that beta-thalassemia homozygous children with severe anemia over 30 ± 0.9 g/L of total Hb with microcytosis of 60,80 ± 2.014 fl, hypochromia 18.47 ± 0.6023 pg and the number of red blood cells is 3.220 ± 0.2778 (10¹²/L). In addition, a significantly secondary thrombocytosis and leukocytosis were reported in patients. Thus the electrophoresis of hemoglobin exhibits a high Hb F (55 to 82%). The peripheral smear examination revealed many red cell abnormalities in the blood. In this study, we used the mini sequencing assay as a rapid screening procedure to identify the severe codon 39 (C>T) mutation in the HBB gene. Phenotype of beta thalassemia major is characterized with various hematological parameters.

In this paper, a simulation study of the maximum power point tracking (MPPT) for a photovoltaic system using an artificial neural network is presented. Maximum power point tracking (MPPT) plays an important role in photovoltaic systems because it maximizes the power output from a PV solar system for all temperature and irradiation conditions, and therefore maximizes the power efficiency. Since the maximum power point (MPP) varies, based on the PV irradiation and temperature, appropriate algorithms must be utilized to track it in order maintain the optimal operation of the system. The software Matlab/Simulink is used to develop the model of PV solar system MPPT controller. The system simulation is elaborated by combining the models established of solar PV module and a DC/DC Boost converter. The system is studied using various irradiance shading conditions. Simulation results show that the photovoltaic simulation system tracks optimally the maximum power point even under severe disturbances conditions.

The paper proposes a new reliable fault-tolerant scheduling algorithm for real-time embedded systems. The proposed scheduling algorithm takes into consideration only one bus fault in multi-bus heterogeneous architectures, caused by hardware faults and compensated by software redundancy solutions. The proposed algorithm is based on both active and passive backup copies, to minimize the scheduling length of data on buses. In the experiments, this paper evaluates the proposed methods in terms of data scheduling length for a set of DAG benchmarks. The experimental results show the effectiveness of our technique.

The coupled finite element method - finite volume method are applied to solve magnetohydrodynamic (MHD) flow equations and the thermal equation in the linear induction MHD pump taking into account the saturation of the ferromagnetic materials. This study is done using the stream-vorticity formulation. The purpose of this paper is to represent the velocity and the temperature respectively in linear and non linear cases because it is required to have the knowledge of the flow and the temperature to design an MHD pump. Additionally, the effect of the electromagnetic thrust on the flow distribution in a linear induction MHD pump is studied.

This work is located in the domain of distributed information retrieval (DIR). A simplified view of the DIR requires a multi-search in a set of collections, which forces the system to analyze results found in these collections, and merge results back before sending them to the user in a single list. Our work is to find a fusion method based on the relevance score of each result received from collections and the relevance of the local search engine of each collection, which is the main issue of our work.

In this paper, versatile structures based on dissimilar metallic nano-particles (Ag, Au, Ti, Al) are proposed to enhance the ZnO thin film optical performance for both optoelectronic and environment monitoring applications. An Exhaustive study of the proposed structure including metallic nano-particles has been performed numerically, in order to evaluate the optical behavior of the proposed ZnO thin films against the conventional design for optoelectronic applications. The numerical computations reveal that the proposed design exhibits an outstanding capability in improving the overall device optical parameters. In addition, the proposed device with Al metallic nano-particles offers superior absorbance as well as lower reflectance as compared to the conventional design. These achievements can be attributed essentially to the localized surface plasma resonance phenomenon and the improved light trapping capability resulted from the optical confinement effect. The recorded results signify the crucial role of the proposed feature in improving the ZnO thin films optical performance, which makes it very promising to be used in the future high performance optoelectronic devices.

In this paper, versatile structures based on dissimilar metallic nano-particles (Ag, Au, Ti, Al) are proposed to enhance the ZnO thin film optical performance for both optoelectronic and environment monitoring applications. An Exhaustive study of the proposed structure including metallic nano-particles has been performed numerically, in order to evaluate the optical behavior of the proposed ZnO thin films against the conventional design for optoelectronic applications. The numerical computations reveal that the proposed design exhibits an outstanding capability in improving the overall device optical parameters. In addition, the proposed device with Al metallic nano-particles offers superior absorbance as well as lower reflectance as compared to the conventional design. These achievements can be attributed essentially to the localized surface plasma resonance phenomenon and the improved light trapping capability resulted from the optical confinement effect. The recorded results signify the crucial role of the proposed feature in improving the ZnO thin films optical performance, which makes it very promising to be used in the future high performance optoelectronic devices.

Introduction: Chronic myeloid leukemia (CML) accounts for 7%-15% of all leukemias affecting adults. The incidence in Algeria is 0.4/100,000 inhabitants in 2009. The aim of this study is to establish an Algerian-Tunisian epidemiological approach of CML and to know the characteristics of the disease in both countries. Materials and methods: This is a retrospective, longitudinal and multicenter study, including Algerian and Tunisian patients with CML diagnosed between January 2010 and December 2014. Through a data form distributed to various hematology departments, we collected and analyzed the following information: Patient’s general characteristics, profession, circumstances of discovery of the disease, clinical and para-clinical examinations outcomes at the time of diagnosis including blood count, blood smear, bone marrow aspiration, cytogenetics, molecular biology, stages of the disease and the Sokal and Eutos prognostic classification scores. Bio-statistical tests: incidence, prevalence and rate of prevalence or relative prevalence (reported to 100,000 inhabitants / year). The descriptive analysis of quantitative and qualitative variables as percentages and 95% confidence interval. The Chi2 test is used to compare two variables. Results: We collected 1349 cases, including 325 from 06 Tunisian hematology units and 1024 from 18 Algerian units. The incidence in the Algerian-Tunisian population was 0.67/100,000 inhabitants with a prevalence rate of 2.72/100,000 inhabitants. The incidence in Tunisia was 0.50 / 100,000 inhabitants with a prevalence of 227 cases in 2014. In Algeria the incidence was 0.53/100,000 inhabitants with a prevalence of 1030 in 2014. The median age is 48 years (03-90) with a peak incidence in the age group (45-49 ans) and slight male predominance (sex ratio: 1,2). There was any notion of risk exposure. The average time between the start of the unrest and the date of diagnosis is 127 days (1-667). The circumstances of discovery: fortuitous in 30.5% (n = 355), splenomegaly in 39.7% (n = 463), asthenia in 24.6% (n = 287), a complication in 8.4% (n =95). Clinical examination includes general signs in 424 cases (36.4%): Weight loss 22.6% (n = 263), profuse sweating 13.8% (n = 13, 8%), bone pains found in 7.8%, splenomegaly in 81.7% (n = 952) with an overhang splenic average of 11.5 ± 5.3 cm (1-28), cutaneous and subcutaneous bleeding: 13.5% (n = 97), thrombosis 0.9% (n = 09). Biological characteristics: the Complete blood count (n = 1185) shows a white blood cells average rate of 171,223 G/L (34,700-984,800), hemoglobin average rate of 10.2 g/dl (4-17), platelets at 394,070 g/l (85-1340). Blood smear 96.3% (n = 1121): the average myelemia was 43.2% (10-98%). The Myelogram is practiced in 55% (n = 641), the average rate of the granular 76,5% (40-99%), erythroblasts 10.5% (0-82%), average blasts 3.6%. The karyotype 38.1% (n = 444), the Philadelphia chromosome was found in 423 cases (95, 3%); additional abnormalities were found in 17 cases (3.8%). The Fish was practiced in 281 cases (24.1%) and transcribed bcr/abl was found in 257 cases (91.4%). Molecular biology is practiced in 672 cases (57.7%) the transcript bcr/abl is found in 100%, the transcript of the type is specified in 373 cases, it is kind of b2a2 in 159 cases (42.6%), a b3a2 type in 180 cases (48.3%) and other transcribed in 34 cases (9.1%). CML chronic phase is diagnosed in 88.8% (n = 1051), acceleration phase in 9% (n = 107) acutisation phase in 3.1% (= 37). The distribution of pts according to Sokal prognostic classification (n = 948) describes a predominance of intermediate risk in 54% (n = 511), high risk in 30.3% (n = 287) and low risk in 16% (n = 152). The Eutos score is specified in 769 cases (66%), it is less than 87 in 661 cases (86%) and more than 87 in 108 cases (14%). Conclusion: The incidence of CML in the Algerian-Tunisian population is 0.67/100,000 population with a prevalence rate of 2.72/100,000 inhabitants. The young adult is more affected with a peak incidence between 45 and 49. The average time between the onset of the disease and the diagnosis remains long and the delay probably explains the frequency of tumor forms encountered in Algeria and the prevalence of high and intermediate risk, according to Sokal prognostic classification. Disclosures No relevant conflicts of interest to declare.