Bioinformatics as a newly emerging discipline is considered nowadays a reference to characterize the physicochemical and pharmacological properties of the actual biocompounds contained in plants, which has helped the pharmaceutical industry a lot in the drug development process. In this study, a bioinformatics approach known as in silico was performed to predict, for the first time, the physicochemical properties, ADMET profile, pharmacological capacities, cytotoxicity, and nervous system macromolecular targets, as well as the gene expression profiles, of four compounds recently identified from Centaurea tougourensis via the gas chromatography–mass spectrometry (GC–MS) approach. Thus, four compounds were tested from the n-butanol (n-BuOH) extract of this plant, named, respectively, Acridin-9-amine, 1,2,3,4-tetrahydro-5,7-dimethyl- (compound 1), 3-[2,3-Dihydro-2,2-dimethylbenzofuran-7-yl]-5-methoxy-1,3,4-oxadiazol-2(3H)-one (compound 2), 9,9-Dimethoxybicyclo[3.3.1]nona-2,4-dione (compound 3), and 3-[3-Bromophenyl]-7-chloro-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione (compound 4). The insilico investigation revealed that the four tested compounds could be a good candidate to regulate the expression of key genes and may also exert significant cytotoxic effects against several tumor celllines. In addition, these compounds could also be effective in the treatment of some diseases related to diabetes, skin pathologies, cardiovascular, and central nervous system disorders. The bioactive compounds of plant remain the best alternative in the context of the drug discovery and development process.

Bioinformatics as a newly emerging discipline is considered nowadays a reference to characterize the physicochemical and pharmacological properties of the actual biocompounds contained in plants, which has helped the pharmaceutical industry a lot in the drug development process. In this study, a bioinformatics approach known as in silico was performed to predict, for the first time, the physicochemical properties, ADMET profile, pharmacological capacities, cytotoxicity, and nervous system macromolecular targets, as well as the gene expression profiles, of four compounds recently identified from Centaurea tougourensis via the gas chromatography–mass spectrometry (GC–MS) approach. Thus, four compounds were tested from the n-butanol (n-BuOH) extract of this plant, named, respectively, Acridin-9-amine, 1,2,3,4-tetrahydro-5,7-dimethyl- (compound 1), 3-[2,3-Dihydro-2,2-dimethylbenzofuran-7-yl]-5-methoxy-1,3,4-oxadiazol-2(3H)-one (compound 2), 9,9-Dimethoxybicyclo[3.3.1]nona-2,4-dione (compound 3), and 3-[3-Bromophenyl]-7-chloro-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione (compound 4). The insilico investigation revealed that the four tested compounds could be a good candidate to regulate the expression of key genes and may also exert significant cytotoxic effects against several tumor celllines. In addition, these compounds could also be effective in the treatment of some diseases related to diabetes, skin pathologies, cardiovascular, and central nervous system disorders. The bioactive compounds of plant remain the best alternative in the context of the drug discovery and development process.

Bioinformatics as a newly emerging discipline is considered nowadays a reference to characterize the physicochemical and pharmacological properties of the actual biocompounds contained in plants, which has helped the pharmaceutical industry a lot in the drug development process. In this study, a bioinformatics approach known as in silico was performed to predict, for the first time, the physicochemical properties, ADMET profile, pharmacological capacities, cytotoxicity, and nervous system macromolecular targets, as well as the gene expression profiles, of four compounds recently identified from Centaurea tougourensis via the gas chromatography–mass spectrometry (GC–MS) approach. Thus, four compounds were tested from the n-butanol (n-BuOH) extract of this plant, named, respectively, Acridin-9-amine, 1,2,3,4-tetrahydro-5,7-dimethyl- (compound 1), 3-[2,3-Dihydro-2,2-dimethylbenzofuran-7-yl]-5-methoxy-1,3,4-oxadiazol-2(3H)-one (compound 2), 9,9-Dimethoxybicyclo[3.3.1]nona-2,4-dione (compound 3), and 3-[3-Bromophenyl]-7-chloro-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione (compound 4). The insilico investigation revealed that the four tested compounds could be a good candidate to regulate the expression of key genes and may also exert significant cytotoxic effects against several tumor celllines. In addition, these compounds could also be effective in the treatment of some diseases related to diabetes, skin pathologies, cardiovascular, and central nervous system disorders. The bioactive compounds of plant remain the best alternative in the context of the drug discovery and development process.

Bioinformatics as a newly emerging discipline is considered nowadays a reference to characterize the physicochemical and pharmacological properties of the actual biocompounds contained in plants, which has helped the pharmaceutical industry a lot in the drug development process. In this study, a bioinformatics approach known as in silico was performed to predict, for the first time, the physicochemical properties, ADMET profile, pharmacological capacities, cytotoxicity, and nervous system macromolecular targets, as well as the gene expression profiles, of four compounds recently identified from Centaurea tougourensis via the gas chromatography–mass spectrometry (GC–MS) approach. Thus, four compounds were tested from the n-butanol (n-BuOH) extract of this plant, named, respectively, Acridin-9-amine, 1,2,3,4-tetrahydro-5,7-dimethyl- (compound 1), 3-[2,3-Dihydro-2,2-dimethylbenzofuran-7-yl]-5-methoxy-1,3,4-oxadiazol-2(3H)-one (compound 2), 9,9-Dimethoxybicyclo[3.3.1]nona-2,4-dione (compound 3), and 3-[3-Bromophenyl]-7-chloro-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione (compound 4). The insilico investigation revealed that the four tested compounds could be a good candidate to regulate the expression of key genes and may also exert significant cytotoxic effects against several tumor celllines. In addition, these compounds could also be effective in the treatment of some diseases related to diabetes, skin pathologies, cardiovascular, and central nervous system disorders. The bioactive compounds of plant remain the best alternative in the context of the drug discovery and development process.

Bioinformatics as a newly emerging discipline is considered nowadays a reference to characterize the physicochemical and pharmacological properties of the actual biocompounds contained in plants, which has helped the pharmaceutical industry a lot in the drug development process. In this study, a bioinformatics approach known as in silico was performed to predict, for the first time, the physicochemical properties, ADMET profile, pharmacological capacities, cytotoxicity, and nervous system macromolecular targets, as well as the gene expression profiles, of four compounds recently identified from Centaurea tougourensis via the gas chromatography–mass spectrometry (GC–MS) approach. Thus, four compounds were tested from the n-butanol (n-BuOH) extract of this plant, named, respectively, Acridin-9-amine, 1,2,3,4-tetrahydro-5,7-dimethyl- (compound 1), 3-[2,3-Dihydro-2,2-dimethylbenzofuran-7-yl]-5-methoxy-1,3,4-oxadiazol-2(3H)-one (compound 2), 9,9-Dimethoxybicyclo[3.3.1]nona-2,4-dione (compound 3), and 3-[3-Bromophenyl]-7-chloro-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione (compound 4). The insilico investigation revealed that the four tested compounds could be a good candidate to regulate the expression of key genes and may also exert significant cytotoxic effects against several tumor celllines. In addition, these compounds could also be effective in the treatment of some diseases related to diabetes, skin pathologies, cardiovascular, and central nervous system disorders. The bioactive compounds of plant remain the best alternative in the context of the drug discovery and development process.

Bioinformatics as a newly emerging discipline is considered nowadays a reference to characterize the physicochemical and pharmacological properties of the actual biocompounds contained in plants, which has helped the pharmaceutical industry a lot in the drug development process. In this study, a bioinformatics approach known as in silico was performed to predict, for the first time, the physicochemical properties, ADMET profile, pharmacological capacities, cytotoxicity, and nervous system macromolecular targets, as well as the gene expression profiles, of four compounds recently identified from Centaurea tougourensis via the gas chromatography–mass spectrometry (GC–MS) approach. Thus, four compounds were tested from the n-butanol (n-BuOH) extract of this plant, named, respectively, Acridin-9-amine, 1,2,3,4-tetrahydro-5,7-dimethyl- (compound 1), 3-[2,3-Dihydro-2,2-dimethylbenzofuran-7-yl]-5-methoxy-1,3,4-oxadiazol-2(3H)-one (compound 2), 9,9-Dimethoxybicyclo[3.3.1]nona-2,4-dione (compound 3), and 3-[3-Bromophenyl]-7-chloro-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione (compound 4). The insilico investigation revealed that the four tested compounds could be a good candidate to regulate the expression of key genes and may also exert significant cytotoxic effects against several tumor celllines. In addition, these compounds could also be effective in the treatment of some diseases related to diabetes, skin pathologies, cardiovascular, and central nervous system disorders. The bioactive compounds of plant remain the best alternative in the context of the drug discovery and development process.

Bioinformatics as a newly emerging discipline is considered nowadays a reference to characterize the physicochemical and pharmacological properties of the actual biocompounds contained in plants, which has helped the pharmaceutical industry a lot in the drug development process. In this study, a bioinformatics approach known as in silico was performed to predict, for the first time, the physicochemical properties, ADMET profile, pharmacological capacities, cytotoxicity, and nervous system macromolecular targets, as well as the gene expression profiles, of four compounds recently identified from Centaurea tougourensis via the gas chromatography–mass spectrometry (GC–MS) approach. Thus, four compounds were tested from the n-butanol (n-BuOH) extract of this plant, named, respectively, Acridin-9-amine, 1,2,3,4-tetrahydro-5,7-dimethyl- (compound 1), 3-[2,3-Dihydro-2,2-dimethylbenzofuran-7-yl]-5-methoxy-1,3,4-oxadiazol-2(3H)-one (compound 2), 9,9-Dimethoxybicyclo[3.3.1]nona-2,4-dione (compound 3), and 3-[3-Bromophenyl]-7-chloro-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione (compound 4). The insilico investigation revealed that the four tested compounds could be a good candidate to regulate the expression of key genes and may also exert significant cytotoxic effects against several tumor celllines. In addition, these compounds could also be effective in the treatment of some diseases related to diabetes, skin pathologies, cardiovascular, and central nervous system disorders. The bioactive compounds of plant remain the best alternative in the context of the drug discovery and development process.

In this work, an inverted PTB7:PC₇₀BM bulk heterojunction solar cells with the configuration of ITO/ZnO/ PTB7:PC₇₀BM / HTMs/Ag for various inorganic materials as a hole transport layer (ZnO, MoO₃, NiO, PEDOT: PSS, V₂O₅ and Cu₂O) are simulated by using the GPVDM software which is a free general-purpose tool for the simulation of opto-electronic devices. The influence of the thickness of both PTB7:PC₇₀BM and HTMs layers on the performance of the solar cell are investigated. The obtained results indicated that on regardless on the type of the inorganic material constituted the Hole Transport Material (HTM), the solar cell parameters can be improved by reducing the HTM thickness while the active layer optimum thickness is around 90 nm. The performance of the device with all inorganic materials used as HTM reaches the same levels as the PEDOT/PSS for the lower thickness (10 nm). As the thickness is increased, the electrical parameters are significantly enhanced by inserting cuprous oxide (Cu₂O) compared to the conventional PEDOT: PSS.

In this work, an inverted PTB7:PC₇₀BM bulk heterojunction solar cells with the configuration of ITO/ZnO/ PTB7:PC₇₀BM / HTMs/Ag for various inorganic materials as a hole transport layer (ZnO, MoO₃, NiO, PEDOT: PSS, V₂O₅ and Cu₂O) are simulated by using the GPVDM software which is a free general-purpose tool for the simulation of opto-electronic devices. The influence of the thickness of both PTB7:PC₇₀BM and HTMs layers on the performance of the solar cell are investigated. The obtained results indicated that on regardless on the type of the inorganic material constituted the Hole Transport Material (HTM), the solar cell parameters can be improved by reducing the HTM thickness while the active layer optimum thickness is around 90 nm. The performance of the device with all inorganic materials used as HTM reaches the same levels as the PEDOT/PSS for the lower thickness (10 nm). As the thickness is increased, the electrical parameters are significantly enhanced by inserting cuprous oxide (Cu₂O) compared to the conventional PEDOT: PSS.

In this work, an inverted PTB7:PC₇₀BM bulk heterojunction solar cells with the configuration of ITO/ZnO/ PTB7:PC₇₀BM / HTMs/Ag for various inorganic materials as a hole transport layer (ZnO, MoO₃, NiO, PEDOT: PSS, V₂O₅ and Cu₂O) are simulated by using the GPVDM software which is a free general-purpose tool for the simulation of opto-electronic devices. The influence of the thickness of both PTB7:PC₇₀BM and HTMs layers on the performance of the solar cell are investigated. The obtained results indicated that on regardless on the type of the inorganic material constituted the Hole Transport Material (HTM), the solar cell parameters can be improved by reducing the HTM thickness while the active layer optimum thickness is around 90 nm. The performance of the device with all inorganic materials used as HTM reaches the same levels as the PEDOT/PSS for the lower thickness (10 nm). As the thickness is increased, the electrical parameters are significantly enhanced by inserting cuprous oxide (Cu₂O) compared to the conventional PEDOT: PSS.

A new method for predicting the Liquid-Vapor critical point of binary mixture, is presented, which is based in geometrical distances. Actually, the method is based on the minimization of the distance between the experimental and calculated values of the critical temperatures and critical pressures. The SRK and PR equations of state along with classical mixing rules of van der Waals were used as thermodynamic models to calculate the critical point of a given mixture. The proposed method requires that the mixture parameters a, b, and the covolume e = b/v of each equation of state be determined at each iteration by solving the resulting cubic equation. For nine binary mixtures containing: hydrocarbon derivatives, carbon dioxide and alcohols are studied. The AARE of the calculated values is about 0.86% for critical temperature and 2.07% for critical pressure. Good agreements are found between the calculated results and experimental data. The technique is a general purpose one and can be applied in connection with other thermodynamic models.

A new method for predicting the Liquid-Vapor critical point of binary mixture, is presented, which is based in geometrical distances. Actually, the method is based on the minimization of the distance between the experimental and calculated values of the critical temperatures and critical pressures. The SRK and PR equations of state along with classical mixing rules of van der Waals were used as thermodynamic models to calculate the critical point of a given mixture. The proposed method requires that the mixture parameters a, b, and the covolume e = b/v of each equation of state be determined at each iteration by solving the resulting cubic equation. For nine binary mixtures containing: hydrocarbon derivatives, carbon dioxide and alcohols are studied. The AARE of the calculated values is about 0.86% for critical temperature and 2.07% for critical pressure. Good agreements are found between the calculated results and experimental data. The technique is a general purpose one and can be applied in connection with other thermodynamic models.

The risk related to embankment dam breaches needs to be evaluated in order to prepare emergency action plans. The physical and hydrodynamic parameters of the flood wave generated from the dam failure event correspond to various breach parameters, such as width, slope, and formation time. This study aimed to simulate the dam breach failure scenario of the Yabous dam (northeast Algeria) and analyze its influence on the related areas (urban and natural environments) downstream of the dam. The simulation was completed using the sensitivity analysis method to assess the impact of breach parameters and flooding on the dam break scenario. The flood wave propagation associated with the dam break was simulated using the one-dimensional HEC-RAS hydraulic model. This study applied a sensitivity analysis of three breach parameters (slope, width, and formation time) on five sites selected downstream of the embankment dam. The simulation showed that the maximum flow of the flood wave recorded at the level of the breach was 8768 m³/s, which gradually attenuated along the river course to reach 1972.7 m³/s at about 8.5 km downstream the dam. This study established the map of flood risk areas that illustrated zones threatened by the flooding wave triggered by the dam failure due to extreme rainfall events. The sensitivity analysis showed that flood wave flow, height, and width revealed positive and similar changes for the increases in adjustments (±25% and ±50%) of breach width and slope in the five sites. However, flood wave parameters of breach formation time showed significant trends that changed in the opposite direction compared to breach slope and width. Meanwhile, the adjustments (±25% and ±50%) of the flood hydrograph did not significantly influence the flood parameters downstream of the dam. In the present study, the HEC-RAS 1-D modeling demonstrated effectiveness in simulating the propagation of flood waves downstream of the dam in the event of dam failure and highlighted the impact of the breach parameters and the flood hydrographical pattern on flood wave parameters.

The risk related to embankment dam breaches needs to be evaluated in order to prepare emergency action plans. The physical and hydrodynamic parameters of the flood wave generated from the dam failure event correspond to various breach parameters, such as width, slope, and formation time. This study aimed to simulate the dam breach failure scenario of the Yabous dam (northeast Algeria) and analyze its influence on the related areas (urban and natural environments) downstream of the dam. The simulation was completed using the sensitivity analysis method to assess the impact of breach parameters and flooding on the dam break scenario. The flood wave propagation associated with the dam break was simulated using the one-dimensional HEC-RAS hydraulic model. This study applied a sensitivity analysis of three breach parameters (slope, width, and formation time) on five sites selected downstream of the embankment dam. The simulation showed that the maximum flow of the flood wave recorded at the level of the breach was 8768 m³/s, which gradually attenuated along the river course to reach 1972.7 m³/s at about 8.5 km downstream the dam. This study established the map of flood risk areas that illustrated zones threatened by the flooding wave triggered by the dam failure due to extreme rainfall events. The sensitivity analysis showed that flood wave flow, height, and width revealed positive and similar changes for the increases in adjustments (±25% and ±50%) of breach width and slope in the five sites. However, flood wave parameters of breach formation time showed significant trends that changed in the opposite direction compared to breach slope and width. Meanwhile, the adjustments (±25% and ±50%) of the flood hydrograph did not significantly influence the flood parameters downstream of the dam. In the present study, the HEC-RAS 1-D modeling demonstrated effectiveness in simulating the propagation of flood waves downstream of the dam in the event of dam failure and highlighted the impact of the breach parameters and the flood hydrographical pattern on flood wave parameters.

The risk related to embankment dam breaches needs to be evaluated in order to prepare emergency action plans. The physical and hydrodynamic parameters of the flood wave generated from the dam failure event correspond to various breach parameters, such as width, slope, and formation time. This study aimed to simulate the dam breach failure scenario of the Yabous dam (northeast Algeria) and analyze its influence on the related areas (urban and natural environments) downstream of the dam. The simulation was completed using the sensitivity analysis method to assess the impact of breach parameters and flooding on the dam break scenario. The flood wave propagation associated with the dam break was simulated using the one-dimensional HEC-RAS hydraulic model. This study applied a sensitivity analysis of three breach parameters (slope, width, and formation time) on five sites selected downstream of the embankment dam. The simulation showed that the maximum flow of the flood wave recorded at the level of the breach was 8768 m³/s, which gradually attenuated along the river course to reach 1972.7 m³/s at about 8.5 km downstream the dam. This study established the map of flood risk areas that illustrated zones threatened by the flooding wave triggered by the dam failure due to extreme rainfall events. The sensitivity analysis showed that flood wave flow, height, and width revealed positive and similar changes for the increases in adjustments (±25% and ±50%) of breach width and slope in the five sites. However, flood wave parameters of breach formation time showed significant trends that changed in the opposite direction compared to breach slope and width. Meanwhile, the adjustments (±25% and ±50%) of the flood hydrograph did not significantly influence the flood parameters downstream of the dam. In the present study, the HEC-RAS 1-D modeling demonstrated effectiveness in simulating the propagation of flood waves downstream of the dam in the event of dam failure and highlighted the impact of the breach parameters and the flood hydrographical pattern on flood wave parameters.

The risk related to embankment dam breaches needs to be evaluated in order to prepare emergency action plans. The physical and hydrodynamic parameters of the flood wave generated from the dam failure event correspond to various breach parameters, such as width, slope, and formation time. This study aimed to simulate the dam breach failure scenario of the Yabous dam (northeast Algeria) and analyze its influence on the related areas (urban and natural environments) downstream of the dam. The simulation was completed using the sensitivity analysis method to assess the impact of breach parameters and flooding on the dam break scenario. The flood wave propagation associated with the dam break was simulated using the one-dimensional HEC-RAS hydraulic model. This study applied a sensitivity analysis of three breach parameters (slope, width, and formation time) on five sites selected downstream of the embankment dam. The simulation showed that the maximum flow of the flood wave recorded at the level of the breach was 8768 m³/s, which gradually attenuated along the river course to reach 1972.7 m³/s at about 8.5 km downstream the dam. This study established the map of flood risk areas that illustrated zones threatened by the flooding wave triggered by the dam failure due to extreme rainfall events. The sensitivity analysis showed that flood wave flow, height, and width revealed positive and similar changes for the increases in adjustments (±25% and ±50%) of breach width and slope in the five sites. However, flood wave parameters of breach formation time showed significant trends that changed in the opposite direction compared to breach slope and width. Meanwhile, the adjustments (±25% and ±50%) of the flood hydrograph did not significantly influence the flood parameters downstream of the dam. In the present study, the HEC-RAS 1-D modeling demonstrated effectiveness in simulating the propagation of flood waves downstream of the dam in the event of dam failure and highlighted the impact of the breach parameters and the flood hydrographical pattern on flood wave parameters.

The risk related to embankment dam breaches needs to be evaluated in order to prepare emergency action plans. The physical and hydrodynamic parameters of the flood wave generated from the dam failure event correspond to various breach parameters, such as width, slope, and formation time. This study aimed to simulate the dam breach failure scenario of the Yabous dam (northeast Algeria) and analyze its influence on the related areas (urban and natural environments) downstream of the dam. The simulation was completed using the sensitivity analysis method to assess the impact of breach parameters and flooding on the dam break scenario. The flood wave propagation associated with the dam break was simulated using the one-dimensional HEC-RAS hydraulic model. This study applied a sensitivity analysis of three breach parameters (slope, width, and formation time) on five sites selected downstream of the embankment dam. The simulation showed that the maximum flow of the flood wave recorded at the level of the breach was 8768 m³/s, which gradually attenuated along the river course to reach 1972.7 m³/s at about 8.5 km downstream the dam. This study established the map of flood risk areas that illustrated zones threatened by the flooding wave triggered by the dam failure due to extreme rainfall events. The sensitivity analysis showed that flood wave flow, height, and width revealed positive and similar changes for the increases in adjustments (±25% and ±50%) of breach width and slope in the five sites. However, flood wave parameters of breach formation time showed significant trends that changed in the opposite direction compared to breach slope and width. Meanwhile, the adjustments (±25% and ±50%) of the flood hydrograph did not significantly influence the flood parameters downstream of the dam. In the present study, the HEC-RAS 1-D modeling demonstrated effectiveness in simulating the propagation of flood waves downstream of the dam in the event of dam failure and highlighted the impact of the breach parameters and the flood hydrographical pattern on flood wave parameters.

The risk related to embankment dam breaches needs to be evaluated in order to prepare emergency action plans. The physical and hydrodynamic parameters of the flood wave generated from the dam failure event correspond to various breach parameters, such as width, slope, and formation time. This study aimed to simulate the dam breach failure scenario of the Yabous dam (northeast Algeria) and analyze its influence on the related areas (urban and natural environments) downstream of the dam. The simulation was completed using the sensitivity analysis method to assess the impact of breach parameters and flooding on the dam break scenario. The flood wave propagation associated with the dam break was simulated using the one-dimensional HEC-RAS hydraulic model. This study applied a sensitivity analysis of three breach parameters (slope, width, and formation time) on five sites selected downstream of the embankment dam. The simulation showed that the maximum flow of the flood wave recorded at the level of the breach was 8768 m³/s, which gradually attenuated along the river course to reach 1972.7 m³/s at about 8.5 km downstream the dam. This study established the map of flood risk areas that illustrated zones threatened by the flooding wave triggered by the dam failure due to extreme rainfall events. The sensitivity analysis showed that flood wave flow, height, and width revealed positive and similar changes for the increases in adjustments (±25% and ±50%) of breach width and slope in the five sites. However, flood wave parameters of breach formation time showed significant trends that changed in the opposite direction compared to breach slope and width. Meanwhile, the adjustments (±25% and ±50%) of the flood hydrograph did not significantly influence the flood parameters downstream of the dam. In the present study, the HEC-RAS 1-D modeling demonstrated effectiveness in simulating the propagation of flood waves downstream of the dam in the event of dam failure and highlighted the impact of the breach parameters and the flood hydrographical pattern on flood wave parameters.

The risk related to embankment dam breaches needs to be evaluated in order to prepare emergency action plans. The physical and hydrodynamic parameters of the flood wave generated from the dam failure event correspond to various breach parameters, such as width, slope, and formation time. This study aimed to simulate the dam breach failure scenario of the Yabous dam (northeast Algeria) and analyze its influence on the related areas (urban and natural environments) downstream of the dam. The simulation was completed using the sensitivity analysis method to assess the impact of breach parameters and flooding on the dam break scenario. The flood wave propagation associated with the dam break was simulated using the one-dimensional HEC-RAS hydraulic model. This study applied a sensitivity analysis of three breach parameters (slope, width, and formation time) on five sites selected downstream of the embankment dam. The simulation showed that the maximum flow of the flood wave recorded at the level of the breach was 8768 m³/s, which gradually attenuated along the river course to reach 1972.7 m³/s at about 8.5 km downstream the dam. This study established the map of flood risk areas that illustrated zones threatened by the flooding wave triggered by the dam failure due to extreme rainfall events. The sensitivity analysis showed that flood wave flow, height, and width revealed positive and similar changes for the increases in adjustments (±25% and ±50%) of breach width and slope in the five sites. However, flood wave parameters of breach formation time showed significant trends that changed in the opposite direction compared to breach slope and width. Meanwhile, the adjustments (±25% and ±50%) of the flood hydrograph did not significantly influence the flood parameters downstream of the dam. In the present study, the HEC-RAS 1-D modeling demonstrated effectiveness in simulating the propagation of flood waves downstream of the dam in the event of dam failure and highlighted the impact of the breach parameters and the flood hydrographical pattern on flood wave parameters.

The risk related to embankment dam breaches needs to be evaluated in order to prepare emergency action plans. The physical and hydrodynamic parameters of the flood wave generated from the dam failure event correspond to various breach parameters, such as width, slope, and formation time. This study aimed to simulate the dam breach failure scenario of the Yabous dam (northeast Algeria) and analyze its influence on the related areas (urban and natural environments) downstream of the dam. The simulation was completed using the sensitivity analysis method to assess the impact of breach parameters and flooding on the dam break scenario. The flood wave propagation associated with the dam break was simulated using the one-dimensional HEC-RAS hydraulic model. This study applied a sensitivity analysis of three breach parameters (slope, width, and formation time) on five sites selected downstream of the embankment dam. The simulation showed that the maximum flow of the flood wave recorded at the level of the breach was 8768 m³/s, which gradually attenuated along the river course to reach 1972.7 m³/s at about 8.5 km downstream the dam. This study established the map of flood risk areas that illustrated zones threatened by the flooding wave triggered by the dam failure due to extreme rainfall events. The sensitivity analysis showed that flood wave flow, height, and width revealed positive and similar changes for the increases in adjustments (±25% and ±50%) of breach width and slope in the five sites. However, flood wave parameters of breach formation time showed significant trends that changed in the opposite direction compared to breach slope and width. Meanwhile, the adjustments (±25% and ±50%) of the flood hydrograph did not significantly influence the flood parameters downstream of the dam. In the present study, the HEC-RAS 1-D modeling demonstrated effectiveness in simulating the propagation of flood waves downstream of the dam in the event of dam failure and highlighted the impact of the breach parameters and the flood hydrographical pattern on flood wave parameters.