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In situ one pot hemi-synthesis of new 2-pyridone derivatives

Citation:

HAFFAS M, Benkiki N, MAADADI R, TALHI O, BOUKENTOUCHA C, CHEBROUK F, Kabouche Z. In situ one pot hemi-synthesis of new 2-pyridone derivatives. Chem. Proc [Internet]. 2021;3.

Abstract:

New 2-pyridone derivatives were hemi-synthetised in situ using essential oils of endemic Algerian plants; Ammodaucus Leucotrichus and eucalyptus citriodora as source of chiral aldehydes (perillaldehyde and citronellal respectively). The one pot reaction was carried out in Ethanol including cyanoacetohydrazide, essential oil, and malononitrile. The reaction mixture was catalysed by potassium carbonate. In the present work, two new compounds of highly functionalized 2-pyridones were obtained as privileged medicinal scaffolds. The structures of 2-pyridone derivatives were confirmed by 1H NMR, 13C and 2D

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Last updated on 06/01/2022