This article aims to propose a model for analyzing work situations. In this context, we focus our interest on the simplification of procedures for working where the proposed model is used to analyze human behavior in response to non-compliance of work procedures. From this analysis, ways to improve work processes will be identified.

Saponins are bioactive compounds occurring in many plant species having a wide range of biological activities such as immunoadjuvant, cytotoxic, analgesic, antimicrobial and anti-inflammatory activities, just to mention a few. The aim of our researches concerns the isolation, structural elucidation and biological investigation of saponins from various plant species [1]. In this context, the study of the roots and leaves of Weigela stelzneri(Caprifoliaceae) led to isolation of four new and two known oleanane-type saponins mainly by medium pressure- and vacuum-liquid chromatography on silica gel (normal and reversed-phase RP-18) [1]. The new compounds were elucidated by a combination of spectroscopic techniques including 1D-, 2D-NMR, and mass spectrometry as glycosides of oleanolic acid, three of them being monodesmosides at C-3 with a branched oligosaccharidic chain made of six sugar units, whereas the known ones were hederagenin derivatives. The six compounds were evaluated for their cytotoxicity against a human cancer cell line (colorectal SW480) and a mouse cancer cell line (mammary EMT6), and for their anti-inflammatory activity. The results show that two new compounds differing only by the first sugar unit of the hexasaccharidic chain at C-3 (arabinopyranosyl instead of xylopyranosyl) exhibited the strongest cytotoxicity on both cell lines (IC50 5.41 µM and 1.54 µM, respectively), which was better than those of the positive controls etoposide and methotrexate. Furthermore, they revealed a significant modulatory effect of the IL-1β production on human lymphocytes stimulated with endotoxins, showing therefore a strong anti-inflammatory potential.